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Effect of Poloxamer 188 vs Placebo on Painful Vaso-Occlusive Episodes in Children and Adults With Sickle Cell Disease: A Randomized Clinical Trial.

dc.contributor.authorSalman, Emad
dc.contributor.authorOwen, William C
dc.contributor.authorSchaefer, Anne
dc.contributor.authorTebbi, Cameron K
dc.contributor.authorChantrain, Christophe F
dc.contributor.authorCohen, Debra E
dc.contributor.authorKarakas, Zeynep
dc.contributor.authorPiccone, Connie M
dc.contributor.authorGeorge, Alex
dc.contributor.authorFixler, Jason M
dc.contributor.authorSingleton, Tammuella C
dc.contributor.authorMoulton, Thomas
dc.contributor.authorQuinn, Charles T
dc.contributor.authorde Castro Lobo, Clarisse Lopes
dc.contributor.authorAlmomen, Abdulkareem M
dc.contributor.authorGoyal-Khemka, Meenakshi
dc.contributor.authorMaes, Philip
dc.contributor.authorEmanuele, Marty
dc.contributor.authorGorney, Rebecca T
dc.contributor.authorPadgett, Claire S
dc.contributor.authorParsley, Ed
dc.contributor.authorKronsberg, Shari S
dc.contributor.authorKato, Gregory J
dc.contributor.authorGladwin, Mark T
dc.contributor.authorCasella, James F
dc.contributor.authorBarton, Bruce A
dc.contributor.authorKanter, Julie
dc.contributor.authorBlack, L Vandy
dc.contributor.authorMajumdar, Suvankar
dc.contributor.authorInati, Adlette
dc.contributor.authorWali, Yasser
dc.contributor.authorDrachtman, Richard A
dc.contributor.authorAbboud, Miguel R
dc.contributor.authorKilinc, Yurdanur
dc.contributor.authorFuh, Beng R
dc.contributor.authorAl-Khabori, Murtadha K
dc.contributor.authorTakemoto, Clifford M
dc.contributor.authorSarnaik, Sharada A
dc.contributor.authorShah, Nirmish
dc.contributor.authorMorris, Claudia R
dc.contributor.authorKeates-Baleeiro, Jennifer
dc.contributor.authorRaj, Ashok
dc.contributor.authorAlvarez, Ofelia A
dc.contributor.authorHsu, Lewis L
dc.contributor.authorThompson, Alexis A
dc.contributor.authorSisler, India Y
dc.contributor.authorPace, Betty S
dc.contributor.authorNoronha, Suzie A
dc.contributor.authorLasky, Joseph L
dc.contributor.authorde Julian, Elena Cela
dc.contributor.authorGodder, Kamar
dc.contributor.authorThornburg, Courtney Dawn
dc.contributor.authorKamberos, Natalie L
dc.contributor.authorNuss, Rachelle
dc.contributor.authorMarsh, Anne M
dc.date.accessioned2021-12-10T09:57:13Z
dc.date.available2021-12-10T09:57:13Z
dc.identifier.citationCasella J. F. , Barton B. A. , Kanter J., Black L. V. , Majumdar S., Inati A., Wali Y., Drachtman R. A. , Abboud M. R. , Kilinc Y., et al., "Effect of Poloxamer 188 vs Placebo on Painful Vaso-Occlusive Episodes in Children and Adults With Sickle Cell Disease: A Randomized Clinical Trial.", JAMA, cilt.325, ss.1513-1523, 2021
dc.identifier.issn0098-7484
dc.identifier.othervv_1032021
dc.identifier.otherav_1e936625-79c9-4cf4-80e1-8063d622f105
dc.identifier.urihttp://hdl.handle.net/20.500.12627/168857
dc.identifier.urihttps://doi.org/10.1001/jama.2021.3414
dc.description.abstractKey PointsQuestionCan poloxamer 188, an agent that is reported to reduce blood viscosity and cell-cell interactions, effectively reduce the duration of vaso-occlusive episodes (painful crises) in hospitalized patients with sickle cell disease? FindingsIn this randomized clinical trial that included 388 children and adults with sickle cell disease, treatment with poloxamer 188 vs placebo resulted in mean time to last dose of parenteral opioids during vaso-occlusive episodes of 81.8 vs 77.8 hours, a difference that was not statistically significant. MeaningAmong patients with sickle cell disease, poloxamer 188 did not significantly shorten the duration of painful vaso-occlusive episodes.
dc.language.isoeng
dc.subjectKlinik Tıp
dc.subjectTIP, GENEL & İÇECEK
dc.subjectKlinik Tıp (MED)
dc.titleEffect of Poloxamer 188 vs Placebo on Painful Vaso-Occlusive Episodes in Children and Adults With Sickle Cell Disease: A Randomized Clinical Trial.
dc.typeMakale
dc.relation.journalJAMA
dc.contributor.department, ,
dc.identifier.volume325
dc.identifier.startpage1513
dc.identifier.endpage1523
dc.contributor.firstauthorID2622515


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