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dc.contributor.authorYildiz, Mahmut
dc.contributor.authorMataraci-Kara, Emel
dc.contributor.authorYildirim, Hatice
dc.contributor.authorTUYUN, Amaç Fatih
dc.contributor.authorBayrak, Nilufer
dc.date.accessioned2021-12-10T10:23:54Z
dc.date.available2021-12-10T10:23:54Z
dc.date.issued2021
dc.identifier.citationBayrak N., Yildiz M., Yildirim H., Mataraci-Kara E., TUYUN A. F. , "Novel plastoquinone analogs containing benzocaine and its analogs: structure-based design, synthesis, and structural characterization", RESEARCH ON CHEMICAL INTERMEDIATES, cilt.47, sa.5, ss.2125-2141, 2021
dc.identifier.issn0922-6168
dc.identifier.otherav_3d8bbb0c-7627-4e7f-8ff9-b0404e62e33c
dc.identifier.othervv_1032021
dc.identifier.urihttp://hdl.handle.net/20.500.12627/169811
dc.identifier.urihttps://doi.org/10.1007/s11164-020-04384-5
dc.description.abstractIntroducing new biologically active organic molecules or their analogs into the pharmaceutically important molecules significantly enables the discovery and development of the medicines that improve the health of patients. Chemical synthesis has a key role in pharmaceutical research and development, aiming to design and build molecules with the essential biological activity needed in drugs. For that reason, herein, three series of novel PQ analogs (the nonhalogenated (PQ1-6) and the halogenated PQ analogs (BrPQ1-6 and ClPQ1-6)) containing benzocaine and its analogs were designed and synthesized starting from the commercially available dimethylhydroquinone (1) with benzocaine and its analogs. The structures of all synthesized analogs were characterized by using spectroscopic methods. The in vitro antibacterial and antifungal activities were evaluated for the PQ analogs.
dc.language.isoeng
dc.subjectPhysical Sciences
dc.subjectAlkoloidler
dc.subjectGeneral Chemistry
dc.subjectTemel Bilimler
dc.subjectChemistry (miscellaneous)
dc.subjectBiyokimya
dc.subjectTemel Bilimler (SCI)
dc.subjectKimya
dc.subjectKİMYA, MULTİDİSİPLİNER
dc.titleNovel plastoquinone analogs containing benzocaine and its analogs: structure-based design, synthesis, and structural characterization
dc.typeMakale
dc.relation.journalRESEARCH ON CHEMICAL INTERMEDIATES
dc.contributor.departmentIstanbul University - Cerrahpasa , ,
dc.identifier.volume47
dc.identifier.issue5
dc.identifier.startpage2125
dc.identifier.endpage2141
dc.contributor.firstauthorID2655685


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