dc.contributor.author | Taslimi, Parham | |
dc.contributor.author | ERKAN, SULTAN | |
dc.contributor.author | Taskin, Omer S. | |
dc.contributor.author | Guzel, Emre | |
dc.contributor.author | KOÇYİĞİT, ÜMİT MUHAMMET | |
dc.date.accessioned | 2021-12-10T10:57:01Z | |
dc.date.available | 2021-12-10T10:57:01Z | |
dc.identifier.citation | Guzel E., KOÇYİĞİT Ü. M. , Taslimi P., ERKAN S., Taskin O. S. , "Biologically active phthalocyanine metal complexes: Preparation, evaluation of alpha-glycosidase and anticholinesterase enzyme inhibition activities, and molecular docking studies", JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY, 2021 | |
dc.identifier.issn | 1095-6670 | |
dc.identifier.other | vv_1032021 | |
dc.identifier.other | av_5de15113-c135-40a0-ae96-a42fe140ecc1 | |
dc.identifier.uri | http://hdl.handle.net/20.500.12627/170903 | |
dc.identifier.uri | https://doi.org/10.1002/jbt.22765 | |
dc.description.abstract | In this study, preparation, as well as investigation of alpha-glycosidase and cholinesterase (ChE) enzyme inhibition activities of furan-2-ylmethoxy-substituted compounds 1-7, are reported. Peripherally, tetra-substituted copper and manganese phthalocyanines (5 and 6) were synthesized for the first time. The substitution of furan-2-ylmethoxy groups provides remarkable solubility to the complex and redshift of the phthalocyanines Q-band. Besides, the inhibitory effects of these compounds on acetylcholinesterase (AChE), butyrylcholinesterase (BChE), and alpha-glycosidase (alpha-Gly) enzymes have been investigated. The AChE was inhibited by these compounds (1-7) in low micromolar levels, and K-i values were recorded between 11.17 +/- 1.03 and 83.28 +/- 11.08 mu M. Against the BChE, the compounds demonstrated K-i values from 7.55 +/- 0.98 to 81.35 +/- 12.80 mu M. Also, these compounds (1-7) effectively inhibited alpha-glycosidase, with K-i values in the range of 744.87 +/- 67.33 to 1094.38 +/- 88.91 mu M. For alpha-glycosidase, the most effective K-i values of phthalocyanines 3 and 6 were with K-i values of 744.87 +/- 67.33 and 880.36 +/- 56.77 mu M, respectively. Moreover, the studied metal complexes were docked with target proteins PDB ID: 4PQE, 1P0I, and 3WY1. Pharmacokinetic parameters and secondary chemical interactions that play an active role in interaction were predicted with docking simulation results. Overall, furan-2-ylmethoxy-substituted phthalocyanines can be considered as potential agents for the treatment of Alzheimer's diseases and diabetes mellitus. | |
dc.language.iso | eng | |
dc.subject | Cancer Research | |
dc.subject | Molecular Biology | |
dc.subject | Drug Discovery | |
dc.subject | Aging | |
dc.subject | General Biochemistry, Genetics and Molecular Biology | |
dc.subject | Pharmacology, Toxicology and Pharmaceutics (miscellaneous) | |
dc.subject | Biochemistry | |
dc.subject | Structural Biology | |
dc.subject | Health, Toxicology and Mutagenesis | |
dc.subject | Life Sciences | |
dc.subject | Physical Sciences | |
dc.subject | BİYOKİMYA VE MOLEKÜLER BİYOLOJİ | |
dc.subject | Moleküler Biyoloji ve Genetik | |
dc.subject | Yaşam Bilimleri (LIFE) | |
dc.subject | TOKSİKOLOJİ | |
dc.subject | Farmakoloji ve Toksikoloji | |
dc.subject | Sağlık Bilimleri | |
dc.subject | Eczacılık | |
dc.subject | Meslek Bilimleri | |
dc.subject | Farmasötik Toksikoloji | |
dc.subject | Yaşam Bilimleri | |
dc.subject | Moleküler Biyoloji ve Genetik | |
dc.subject | Sitogenetik | |
dc.subject | Temel Bilimler | |
dc.subject | Biochemistry, Genetics and Molecular Biology (miscellaneous) | |
dc.subject | Toxicology | |
dc.subject | Clinical Biochemistry | |
dc.title | Biologically active phthalocyanine metal complexes: Preparation, evaluation of alpha-glycosidase and anticholinesterase enzyme inhibition activities, and molecular docking studies | |
dc.type | Makale | |
dc.relation.journal | JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY | |
dc.contributor.department | Sakara University of Applied Science , , | |
dc.contributor.firstauthorID | 2604688 | |