dc.contributor.author | Bayrak, Bertan Boran | |
dc.contributor.author | Arda-Pirincci, Pelin | |
dc.contributor.author | Yanardag, Refiye | |
dc.contributor.author | Bolkent, Şehnaz | |
dc.date.accessioned | 2021-12-10T11:08:06Z | |
dc.date.available | 2021-12-10T11:08:06Z | |
dc.identifier.citation | Bayrak B. B. , Arda-Pirincci P., Bolkent Ş., Yanardag R., "Zinc Prevents Ethanol-Induced Oxidative Damage in Lingual Tissues of Rats.", Biological trace element research, 2021 | |
dc.identifier.issn | 0163-4984 | |
dc.identifier.other | vv_1032021 | |
dc.identifier.other | av_6975fb1f-49ae-4441-9988-b138e56597e0 | |
dc.identifier.uri | http://hdl.handle.net/20.500.12627/171271 | |
dc.identifier.uri | https://doi.org/10.1007/s12011-021-02682-6 | |
dc.description.abstract | The current study was designed to investigate the effects of zinc sulfate on cell proliferation, metallothionein (MT) immunoreactivity and antioxidant system against acute ethanol-induced oxidative damage in tongue tissues of rats. Wistar albino male rats, 2.5 to 3.0 months, were divided into four groups: Group I (n = 8), intact control rats; group II (n = 8), control animals given only zinc sulfate (100 mg/kg/day, for 3 consecutive days); group III (n = 14), animals given 1 mL absolute ethanol; group IV (n = 11), animals given zinc sulfate and absolute ethanol at the same dose and time. Animals were sacrificed under anesthesia 2 h after ethanol administration or 4 h after the last zinc sulfate treatment. Ethanol administration caused a marked decrease in the number of MT immunopositive cells and the proliferating cells in the lingual epithelium. A statistically significant decline in reduced glutathione levels, catalase activity and superoxide dismutase activities was also observed, whereas a significant elevation of lipid peroxidation levels and lactate dehydrogenase activities was detected in the ethanol group. In contrast, these changes were reversed by administration of zinc sulfate to ethanol-treated rats. In conclusion, it shows that zinc sulfate has therapeutic effects on acute ethanol-induced oxidative damage in the tongue tissues of rats. | |
dc.language.iso | eng | |
dc.subject | Klinik Tıp | |
dc.subject | Klinik Tıp (MED) | |
dc.subject | ENDOKRİNOLOJİ VE METABOLİZMA | |
dc.subject | Yaşam Bilimleri (LIFE) | |
dc.subject | Moleküler Biyoloji ve Genetik | |
dc.subject | BİYOKİMYA VE MOLEKÜLER BİYOLOJİ | |
dc.title | Zinc Prevents Ethanol-Induced Oxidative Damage in Lingual Tissues of Rats. | |
dc.type | Makale | |
dc.relation.journal | Biological trace element research | |
dc.contributor.department | , , | |
dc.contributor.firstauthorID | 2604428 | |