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dc.contributor.authorRaka, Lul
dc.contributor.authorCarevic, Biljana
dc.contributor.authorEl-Kholy, Amani
dc.contributor.authorLiskova, Anna
dc.contributor.authorÖZDEMİR, MEHMET
dc.contributor.authorKhan, Ejaz Ahmed
dc.contributor.authorUygun-Kizmaz, Yesim
dc.contributor.authorPandak, Nenad
dc.contributor.authorPandya, Nirav
dc.contributor.authorArapovic, Jurica
dc.contributor.authorKARAALİ, Rıdvan
dc.contributor.authorOztoprak, Nefise
dc.contributor.authorPetrov, Michael M.
dc.contributor.authorAlabadla, Rami
dc.contributor.authorALAY, Handan
dc.contributor.authorEl Kholy, Jehan Ali
dc.contributor.authorLandelle, Caroline
dc.contributor.authorKhedr, Reham
dc.contributor.authorMamtora, Dhruv
dc.contributor.authorDragovac, Gorana
dc.contributor.authorFernandez, Ricardo
dc.contributor.authorEvren, Emine Unal
dc.contributor.authorGrgic, Svjetlana
dc.contributor.authorCascio, Antonio
dc.contributor.authorDauby, Nicolas
dc.contributor.authorOncul, Ahsen
dc.contributor.authorBALIN, ŞAFAK ÖZER
dc.contributor.authorÇAĞ, YASEMİN
dc.contributor.authorDirani, Natalia
dc.contributor.authorDOĞAN, MUSTAFA
dc.contributor.authorDumitru, Irina Magdalena
dc.contributor.authorGad, Maha Ali
dc.contributor.authorDarazam, Ilad Alavi
dc.contributor.authorNaghili, Behrouz
dc.contributor.authorDel Vecchio, Rosa Fontana
dc.contributor.authorLicker, Monica
dc.contributor.authorMarino, Andrea
dc.contributor.authorAkhtar, Nasim
dc.contributor.authorKamal, Mostafa
dc.contributor.authorAngioni, Goffredo
dc.contributor.authorMedic, Deana
dc.contributor.authorEsmaoglu, Aliye
dc.contributor.authorGergely, Szabo Balint
dc.contributor.authorSilva-Pinto, Andre
dc.contributor.authorSantos, Lurdes
dc.contributor.authorMiftode, Ionela Larisa
dc.contributor.authorTEKİN, RECEP
dc.contributor.authorWongsurakiat, Phunsup
dc.contributor.authorKhan, Mumtaz Ali
dc.contributor.authorKurekci, Yesim
dc.contributor.authorPilli, Hema Prakash
dc.contributor.authorGrozdanovski, Krsto
dc.contributor.authorMiftode, Egidia
dc.contributor.authorBaljic, Rusmir
dc.contributor.authorVahabolgu, Haluk
dc.contributor.authorRello, Jordi
dc.contributor.authorEl-Sokkary, Rehab
dc.contributor.authorUysal, Serhat
dc.contributor.authorErdem, Hakan
dc.contributor.authorKullar, Ravina
dc.contributor.authorPekok, Abdullah Umut
dc.contributor.authorAmer, Fatma
dc.date.accessioned2021-12-10T11:45:06Z
dc.date.available2021-12-10T11:45:06Z
dc.identifier.citationEl-Sokkary R., Uysal S., Erdem H., Kullar R., Pekok A. U. , Amer F., Grgic S., Carevic B., El-Kholy A., Liskova A., et al., "Profiles of multidrug-resistant organisms among patients with bacteremia in intensive care units: an international ID-IRI survey", EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES, cilt.40, ss.2323-2334, 2021
dc.identifier.issn0934-9723
dc.identifier.othervv_1032021
dc.identifier.otherav_92726902-abd2-450d-8877-f5cdaea53a97
dc.identifier.urihttp://hdl.handle.net/20.500.12627/172548
dc.identifier.urihttps://doi.org/10.1007/s10096-021-04288-1
dc.description.abstractEvaluating trends in antibiotic resistance is a requisite. The study aimed to analyze the profile of multidrug-resistant organisms (MDROs) among hospitalized patients with bacteremia in intensive care units (ICUs) in a large geographical area. This is a 1-month cross-sectional survey for blood-borne pathogens in 57 ICUs from 24 countries with different income levels: lower-middle-income (LMI), upper-middle-income (UMI), and high-income (HI) countries. Multidrug-resistant (MDR), extensively drug-resistant (XDR), or pan-drug-resistant isolates were searched. Logistic regression analysis determined resistance predictors among MDROs. Community-acquired infections were comparable to hospital-acquired infections particularly in LMI (94/202; 46.5% vs 108/202; 53.5%). Although MDR (65.1%; 502/771) and XDR (4.9%; 38/771) were common, no pan-drug-resistant isolate was recovered. In total, 32.1% of MDR were Klebsiella pneumoniae, and 55.3% of XDR were Acinetobacter baumannii. The highest MDR and XDR rates were in UMI and LMI, respectively, with no XDR revealed from HI. Predictors of MDR acquisition were male gender (OR, 12.11; 95% CI, 3.025-15.585) and the hospital-acquired origin of bacteremia (OR, 2.643; 95%CI, 1.462-3.894), and XDR acquisition was due to bacteremia in UMI (OR, 3.344; 95%CI, 1.189-5.626) and admission to medical-surgical ICUs (OR, 1.481; 95% CI, 1.076-2.037). We confirm the urgent need to expand stewardship activities to community settings especially in LMI, with more paid attention to the drugs with a higher potential for resistance. Empowering microbiology laboratories and reports to direct prescribing decisions should be prioritized. Supporting stewardship in ICUs, the mixed medical-surgical ones in particular, is warranted.
dc.language.isoeng
dc.subjectTemel Bilimler
dc.subjectGeneral Immunology and Microbiology
dc.subjectImmunology
dc.subjectInfectious Diseases
dc.subjectLife Sciences
dc.subjectHealth Sciences
dc.subjectBULAŞICI HASTALIKLAR
dc.subjectİmmünoloji
dc.subjectYaşam Bilimleri (LIFE)
dc.subjectMikrobiyoloji
dc.subjectYaşam Bilimleri
dc.titleProfiles of multidrug-resistant organisms among patients with bacteremia in intensive care units: an international ID-IRI survey
dc.typeMakale
dc.relation.journalEUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES
dc.contributor.departmentZagazig University , ,
dc.identifier.volume40
dc.identifier.startpage2323
dc.identifier.endpage2334
dc.contributor.firstauthorID2686381


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