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dc.contributor.authorDogru-Abbasoglu, Semra
dc.contributor.authorTekkesin, Merva
dc.contributor.authorUysal, Mujdat
dc.contributor.authorOlgac, Vakur
dc.contributor.authorBasaran-Kucukgergin, Canan
dc.contributor.authorBingul, Ilknur
dc.date.accessioned2021-03-02T23:17:15Z
dc.date.available2021-03-02T23:17:15Z
dc.date.issued2013
dc.identifier.citationBingul I., Basaran-Kucukgergin C., Tekkesin M., Olgac V., Dogru-Abbasoglu S., Uysal M., "Effect of blueberry pretreatment on diethylnitrosamine-induced oxidative stress and liver injury in rats", ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY, cilt.36, sa.2, ss.529-538, 2013
dc.identifier.issn1382-6689
dc.identifier.othervv_1032021
dc.identifier.otherav_11896536-8fac-4310-96d8-b61f1f7747b4
dc.identifier.urihttp://hdl.handle.net/20.500.12627/17272
dc.identifier.urihttps://doi.org/10.1016/j.etap.2013.05.014
dc.description.abstractDiethylnitrosamine (DEN) treatment increases the generation of reactive oxygen species (ROS), apoptosis, necrosis and proliferation in the liver. Blueberries (BB; Vaccinium corymbosum L.) contain polyphenols and other active components and have high antioxidant capacities. We investigated the effect of BB pretreatment on DEN-induced liver injury and oxidative and nitrosative stress in male rats. Rats were fed with 5% and 10% BB containing diet for six weeks and DEN (200 mg/kg; i.p.) was applied two days before the end of this period. Liver function tests were determined in serum and histopathological evaluation was performed in the liver tissue. Apoptosis-related proteins, Bax and B cell lymphoma-2 (Bcl-2) and proliferating cell nuclear antigen (PCNA) expressions were also examined. Oxidative and nitrosative stress were evaluated in the liver by measuring thiobarbituric acid reactive substances, diene conjugate, protein carbonyl and nitrotyrosine levels, and glutathione levels and glutathione peroxidase, superoxide dismutase and glutathione transferase (GST) activities. Pretreatment with high dose of BB reduced apoptotic, necrotic and proliferative changes in the liver induced by DEN. Dietary BB also decreased hepatic lipid peroxidation, protein oxidation and nitrotyrosine levels together with increased GST activity. In conclusion, BB may have an inhibiting effect on acute liver injury by reducing apoptosis, necrosis, proliferation, oxidative and nitrosative stress in DEN-treated rats. (C) 2013 Elsevier B.V. All rights reserved.
dc.language.isoeng
dc.subjectTemel Eczacılık Bilimleri
dc.subjectÇEVRE BİLİMLERİ
dc.subjectSağlık Bilimleri
dc.subjectEczacılık
dc.subjectMeslek Bilimleri
dc.subjectFarmasötik Toksikoloji
dc.subjectTarımsal Bilimler
dc.subjectÇevre Mühendisliği
dc.subjectYaşam Bilimleri
dc.subjectTemel Bilimler
dc.subjectMühendislik ve Teknoloji
dc.subjectÇevre / Ekoloji
dc.subjectTarım ve Çevre Bilimleri (AGE)
dc.subjectFARMAKOLOJİ VE ECZACILIK
dc.subjectFarmakoloji ve Toksikoloji
dc.subjectYaşam Bilimleri (LIFE)
dc.subjectTOKSİKOLOJİ
dc.titleEffect of blueberry pretreatment on diethylnitrosamine-induced oxidative stress and liver injury in rats
dc.typeMakale
dc.relation.journalENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
dc.contributor.departmentİstanbul Üniversitesi , ,
dc.identifier.volume36
dc.identifier.issue2
dc.identifier.startpage529
dc.identifier.endpage538
dc.contributor.firstauthorID44555


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