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dc.contributor.authorAbuqbeitah, Mohammad
dc.contributor.authorIsikci, Nazenin Ipek
dc.date.accessioned2021-12-10T11:50:57Z
dc.date.available2021-12-10T11:50:57Z
dc.identifier.citationIsikci N. I. , Abuqbeitah M., "Quantitative improvement of lymph nodes visualization of breast cancer using Tc-99m-nanocolloid SPECT/CT and updated reconstruction algorithm", RADIATION AND ENVIRONMENTAL BIOPHYSICS, 2021
dc.identifier.issn0301-634X
dc.identifier.othervv_1032021
dc.identifier.otherav_986a7062-f789-4e61-8a94-261e7fefdf47
dc.identifier.urihttp://hdl.handle.net/20.500.12627/172757
dc.identifier.urihttps://doi.org/10.1007/s00411-021-00914-w
dc.description.abstractThis study aimed to evaluate the impact of attenuation and scatter correction on the contrast to noise ratio values of SPECT and SPECT/CT images in sentinel lymph nodes scintigraphy. In addition, the effect of using an iterative reconstruction algorithm with variable iterations number and fixed subsets was also investigated. 35 patients with a total of 44 lymph nodes were recruited in the current study. SPECT/CT scans were performed 3-4 h following peri-tumoral Tc-99m-nanocolloid injection (approximate to 1 mCi) at four points. Two image types were generated including SPECT with attenuation and scatter correction (AC-SC) and SPECT without any correction (NoAC-NoSC). The acquired projections were repeatedly reconstructed with eight subsets and 10, 20, 30 and 40 iterations. Afterwards, the calculated contrast to noise ratio values were used to investigate the effect of number of iteration and to compare the image quality of SPECT/CT and SPECT only. The mean contrast to noise (CNR) values of SPECT/CT scans were found to be 19,737, 26,418, 34,282 and 31,187 at 10, 20, 30 and 40 iterations, respectively. Whereas, the mean CNR values in SPECT (NoAC-NoSC) were as low as 8506, 10,582, 13,791 and 12,143 at 10, 20, 30 and 40 iterations, respectively. The CNR values of both SPECT and SPECT/CT improved with increasing number of iterations up to 30 iterations and then slightly decreased after 30-40 iterations. Likewise, no significant difference was found between 10 and 20 iterations (P-value = 0.06) in SPECT/CT, while a statistically significant difference was observed between 10 iterations and both 30 and 40 iterations (P-value < 0.05). It is concluded that the attenuation and scatter correction in SPECT/CT optimized the CNR values up to threefold compared to SPECT alone. Thus, a considerable improvement in the CNR values and the image quality can be obtained by increasing the iterations number to peak of 30 iterations.
dc.language.isoeng
dc.subjectBİYOLOJİ
dc.subjectBiyoloji ve Biyokimya
dc.subjectYaşam Bilimleri (LIFE)
dc.subjectTıp
dc.subjectTarımsal Bilimler
dc.subjectÇevre Mühendisliği
dc.subjectYaşam Bilimleri
dc.subjectTemel Bilimler
dc.subjectMühendislik ve Teknoloji
dc.subjectAquatic Science
dc.subjectBiophysics
dc.subjectNature and Landscape Conservation
dc.subjectEnvironmental Science (miscellaneous)
dc.subjectRadiology, Nuclear Medicine and Imaging
dc.subjectBiochemistry (medical)
dc.subjectRadiological and Ultrasound Technology
dc.subjectPhysical Sciences
dc.subjectLife Sciences
dc.subjectBİYOFİZİK
dc.subjectHealth Sciences
dc.subjectÇEVRE BİLİMLERİ
dc.subjectÇevre / Ekoloji
dc.subjectTarım ve Çevre Bilimleri (AGE)
dc.subjectRADYOLOJİ, NÜKLEER TIP ve MEDİKAL GÖRÜNTÜLEME
dc.subjectKlinik Tıp
dc.subjectKlinik Tıp (MED)
dc.subjectSağlık Bilimleri
dc.subjectTemel Tıp Bilimleri
dc.subjectBiyofizik
dc.subjectBiyokimya
dc.subjectTıbbi Biyoloji
dc.subjectDahili Tıp Bilimleri
dc.subjectNükleer Tıp
dc.titleQuantitative improvement of lymph nodes visualization of breast cancer using Tc-99m-nanocolloid SPECT/CT and updated reconstruction algorithm
dc.typeMakale
dc.relation.journalRADIATION AND ENVIRONMENTAL BIOPHYSICS
dc.contributor.departmentNişantaşı Üniversitesi , ,
dc.contributor.firstauthorID2636151


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