dc.contributor.author | Dursun, Memduh | |
dc.contributor.author | Gul, Nurdan | |
dc.contributor.author | Karakas, Zeynep | |
dc.contributor.author | Sevimli, Cihangir | |
dc.contributor.author | Yilmaz, Yasin | |
dc.contributor.author | Bayramoglu, Zuhal | |
dc.contributor.author | Comert, Rana Gunoz | |
dc.date.accessioned | 2021-12-10T11:52:10Z | |
dc.date.available | 2021-12-10T11:52:10Z | |
dc.identifier.citation | Sevimli C., Yilmaz Y., Bayramoglu Z., Comert R. G. , Gul N., Dursun M., Karakas Z., "Pancreatic MR imaging and endocrine complications in patients with beta-thalassemia: a single-center experience", CLINICAL AND EXPERIMENTAL MEDICINE, 2021 | |
dc.identifier.issn | 1591-8890 | |
dc.identifier.other | av_9a2e94bb-f948-4c3d-a66b-5d353d535892 | |
dc.identifier.other | vv_1032021 | |
dc.identifier.uri | http://hdl.handle.net/20.500.12627/172802 | |
dc.identifier.uri | https://doi.org/10.1007/s10238-021-00735-7 | |
dc.description.abstract | Iron deposition in various organs can cause endocrine complications in patients with transfusion-dependent beta-thalassemia. The aim was to investigate the relationship between endocrine complications and pancreatic iron overload using magnetic resonance imaging (MRI). Forty patients with transfusion-dependent thalassemia (TDT) were enrolled in the study. The magnetic resonance imagings of the patients were performed using a 1.5 Tesla Philips MRI scanner. Two out of three patients had at least one clinical endocrine complication. The rate of iron deposition was 62.5% in liver, and 45% in pancreas tissue, and was 12.5% in heart tissue. Pancreatic T2* and hepatic T2* values were significantly positively correlated (p = 0.006). Pancreatic T2* and ferritin were significantly negatively correlated (p = 0.03). Cardiac T2* values were negatively correlated with fasting blood glucose (p = 0.03). Patients with short stature had significantly higher cardiac iron burden (22.3 vs. 36.6 T2*ms; p 0.01), and patients with hypothyroidism had higher liver iron concentrations (9.9 vs. 6.4 LIC mg/g; p = 0.05). The ferritin level of 841 ng/mL and liver iron concentration (LIC) value of 8.7 mg/g were detected as the threshold level for severe pancreatic iron burden (AUC 70%, p:0.04, AUC 80%, p = 0.002, respectively). Moreover, males were found to have decreased pancreas T2* values compared with the values in females (T2* 19.3 vs. 29.9, p = 0.05). Patients with higher ferritin levels over than 840 ng/mL should be closely monitored for pancreatic iron deposition, and patients with endocrine complications should be assessed in terms of cardiac iron burden. | |
dc.language.iso | eng | |
dc.subject | Dahili Tıp Bilimleri | |
dc.subject | Tıp | |
dc.subject | Sağlık Bilimleri | |
dc.subject | TIP, ARAŞTIRMA VE DENEYSEL | |
dc.subject | Klinik Tıp | |
dc.subject | Klinik Tıp (MED) | |
dc.subject | Tıbbi Ekoloji ve Hidroklimatoloji | |
dc.subject | Reviews and References (medical) | |
dc.subject | Research and Theory | |
dc.subject | Health Sciences | |
dc.title | Pancreatic MR imaging and endocrine complications in patients with beta-thalassemia: a single-center experience | |
dc.type | Makale | |
dc.relation.journal | CLINICAL AND EXPERIMENTAL MEDICINE | |
dc.contributor.department | İstanbul Teknik Üniversitesi , , | |
dc.contributor.firstauthorID | 2693453 | |