dc.contributor.author | Akgul, C | |
dc.contributor.author | Vural, P | |
dc.contributor.author | Canbaz, M | |
dc.date.accessioned | 2021-03-02T23:18:16Z | |
dc.date.available | 2021-03-02T23:18:16Z | |
dc.date.issued | 2002 | |
dc.identifier.citation | Akgul C., Canbaz M., Vural P., "Effects of tibolone on endogenous nitric oxide (nitrite/nitrate levels) in postmenopausal women", INTERNATIONAL JOURNAL OF FERTILITY AND WOMENS MEDICINE, cilt.47, sa.1, ss.13-17, 2002 | |
dc.identifier.issn | 1069-3130 | |
dc.identifier.other | vv_1032021 | |
dc.identifier.other | av_11ad393e-6084-4616-b334-efb7e54490ee | |
dc.identifier.uri | http://hdl.handle.net/20.500.12627/17350 | |
dc.description.abstract | Objective-To observe the effects of hormone replacement therapy with 2.5 mg/day tibolone for 6 months upon plasma nitrite/nitrate (end products of nitric oxide metabolism) in postmenopausal women. Patients and Methods-The study involved 24 healthy postmenopausal women treated with tibolone (2.5 mg/day for 6 months) and 20 postmenopausal women who received placebo. Plasma nitrite/nitrate levels were measured with the Griess reaction. Statistical significance was analyzed by the Mann-Whitney U test and Pearson correlation analysis. Results-The mean baseline concentrations of nitrite/nitrate were similar in both treated and placebo groups. Tibolone treatment decreased plasma nitrite/nitrate levels. Conclusions-We suggest that because of its androgenic and progestogenic actions, tibolone diminishes nitrite/nitrate levels. Also our data provide evidence for the existence of increased (1/3 of subjects, n = 8) and reduced (2/3 of subjects, n = 16) nitrite/nitrate levels in response to tibolone treatment. Clearly, further studies are necessary to establish a risk/benefit ratio for tibolone in view of its effects on nitric oxide metabolism. | |
dc.language.iso | eng | |
dc.subject | Tıp | |
dc.subject | Kadın Hastalıkları ve Doğum | |
dc.subject | Sağlık Bilimleri | |
dc.subject | Cerrahi Tıp Bilimleri | |
dc.subject | Klinik Tıp (MED) | |
dc.subject | Klinik Tıp | |
dc.subject | KADIN HASTALIKLARI & DOĞUM | |
dc.title | Effects of tibolone on endogenous nitric oxide (nitrite/nitrate levels) in postmenopausal women | |
dc.type | Makale | |
dc.relation.journal | INTERNATIONAL JOURNAL OF FERTILITY AND WOMENS MEDICINE | |
dc.contributor.department | , , | |
dc.identifier.volume | 47 | |
dc.identifier.issue | 1 | |
dc.identifier.startpage | 13 | |
dc.identifier.endpage | 17 | |
dc.contributor.firstauthorID | 163886 | |