dc.contributor.author | FRANZ, David N. | |
dc.contributor.author | Yapici, Zühal | |
dc.contributor.author | PELOV, Diana | |
dc.contributor.author | French, Jacqueline A. | |
dc.contributor.author | Lawson, John A. | |
dc.contributor.author | Ikeda, Hiroko | |
dc.contributor.author | Polster, Tilman | |
dc.contributor.author | Nobbout, Rima | |
dc.contributor.author | Curatolo, Paolo | |
dc.contributor.author | de Vries, Petrus J. | |
dc.contributor.author | Diugos, Dennis J. | |
dc.contributor.author | Berkowitz, Noah | |
dc.contributor.author | VOI, Maurizio | |
dc.contributor.author | PEYRARD, Severine | |
dc.date.accessioned | 2021-03-02T23:18:42Z | |
dc.date.available | 2021-03-02T23:18:42Z | |
dc.date.issued | 2016 | |
dc.identifier.citation | French J. A. , Lawson J. A. , Yapici Z., Ikeda H., Polster T., Nobbout R., Curatolo P., de Vries P. J. , Diugos D. J. , Berkowitz N., et al., "Adjunctive everolimus therapy for treatment-resistant focal-onset seizures associated with tuberous sclerosis (EXIST-3): a phase 3, randomised, double-blind, placebo-controlled study", LANCET, cilt.388, sa.10056, ss.2153-2163, 2016 | |
dc.identifier.issn | 0140-6736 | |
dc.identifier.other | vv_1032021 | |
dc.identifier.other | av_11be8da4-5afb-4e1f-a72b-2d3dff35fbaf | |
dc.identifier.uri | http://hdl.handle.net/20.500.12627/17382 | |
dc.identifier.uri | https://doi.org/10.1016/s0140-6736(16)31419-2 | |
dc.description.abstract | Background Everolimus, a mammalian target of rapamycin (mTOR) inhibitor, has been used for various benign tumours associated with tuberous sclerosis complex. We assessed the efficacy and safety of two trough exposure concentrations of everolimus, 3-7 ng/mL (low exposure) and 9-15 ng/mL (high exposure), compared with placebo as adjunctive therapy for treatment-resistant focal-onset seizures in tuberous sclerosis complex. | |
dc.language.iso | eng | |
dc.subject | Temel Tıp Bilimleri | |
dc.subject | Sağlık Bilimleri | |
dc.subject | Tıp | |
dc.subject | Klinik Tıp (MED) | |
dc.subject | Klinik Tıp | |
dc.subject | TIP, GENEL & İÇECEK | |
dc.title | Adjunctive everolimus therapy for treatment-resistant focal-onset seizures associated with tuberous sclerosis (EXIST-3): a phase 3, randomised, double-blind, placebo-controlled study | |
dc.type | Makale | |
dc.relation.journal | LANCET | |
dc.contributor.department | NHO Epilepsy Ctr , , | |
dc.identifier.volume | 388 | |
dc.identifier.issue | 10056 | |
dc.identifier.startpage | 2153 | |
dc.identifier.endpage | 2163 | |
dc.contributor.firstauthorID | 52739 | |