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Determination of cyclonite (RDX) in human plasma by high-performance liquid chromatography

dc.contributor.authorTopuz, Sibel
dc.contributor.authorÖZHAN, Gül
dc.contributor.authorALPERTUNGA, Büket
dc.date.accessioned2021-12-10T12:42:56Z
dc.date.available2021-12-10T12:42:56Z
dc.date.issued2003
dc.identifier.citationÖZHAN G., Topuz S., ALPERTUNGA B., "Determination of cyclonite (RDX) in human plasma by high-performance liquid chromatography", Farmaco, cilt.58, sa.6, ss.445-448, 2003
dc.identifier.issn0014-827X
dc.identifier.othervv_1032021
dc.identifier.otherav_d1677236-54c3-4cda-8860-bc636cf41e83
dc.identifier.urihttp://hdl.handle.net/20.500.12627/174487
dc.identifier.urihttps://doi.org/10.1016/s0014-827x(03)00069-7
dc.identifier.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=0038289240&origin=inward
dc.description.abstractA simple and sensitive HPLC method has been developed for the assay of cyclonite (RDX) in human plasma. The assay involves solid-phase extraction on Tox-clean RC SPE cartridges and isocratic reversed-phase chromatography with diode-array detection. The assay was linear over the concentration range of 0.01-2.0 μg/ml for plasma with a lower limit of detection of 0.005 μg/ml. Both the within-day and day-to-day reproducibilities and accuracies were less than 10.15 and 1.9%, respectively. The method was applied to evaluate RDX concentration in plasma samples obtained from soldiers exposed RDX. © 2003 Éditions scientifiques et médicales Elsevier SAS. All rights reserved.
dc.language.isoeng
dc.subjectTemel Bilimler
dc.subjectPharmaceutical Science
dc.subjectLife Sciences
dc.subjectDrug Discovery
dc.subjectKlinik Tıp
dc.subjectMoleküler Biyoloji ve Genetik
dc.subjectTROPİKAL TIP
dc.subjectBİYOKİMYA VE MOLEKÜLER BİYOLOJİ
dc.subjectTıp
dc.subjectSağlık Bilimleri
dc.subjectYaşam Bilimleri
dc.subjectMoleküler Biyoloji ve Genetik
dc.subjectSitogenetik
dc.subjectKlinik Tıp (MED)
dc.subjectYaşam Bilimleri (LIFE)
dc.titleDetermination of cyclonite (RDX) in human plasma by high-performance liquid chromatography
dc.typeMakale
dc.relation.journalFarmaco
dc.contributor.departmentİstanbul Üniversitesi , Eczacılık Fakültesi , Eczacılık Meslek Bilimleri Bölümü
dc.identifier.volume58
dc.identifier.issue6
dc.identifier.startpage445
dc.identifier.endpage448
dc.contributor.firstauthorID2639384


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