dc.contributor.author | Oguz, Nesrin | |
dc.contributor.author | ALARÇİN, EMİNE | |
dc.contributor.author | Sahin, Hande Tekarslan | |
dc.contributor.author | EMİK, Serkan | |
dc.contributor.author | Ozturk, Ayca Bal | |
dc.date.accessioned | 2021-03-02T23:20:48Z | |
dc.date.available | 2021-03-02T23:20:48Z | |
dc.date.issued | 2020 | |
dc.identifier.citation | Ozturk A. B. , Oguz N., Sahin H. T. , EMİK S., ALARÇİN E., "Design of an amphiphilic hyperbranched core/shell-type polymeric nanocarrier platform for drug delivery", TURKISH JOURNAL OF CHEMISTRY, cilt.44, sa.2, ss.518-534, 2020 | |
dc.identifier.issn | 1300-0527 | |
dc.identifier.other | av_11e29214-acf7-474d-9173-d6af0e537f5f | |
dc.identifier.other | vv_1032021 | |
dc.identifier.uri | http://hdl.handle.net/20.500.12627/17487 | |
dc.identifier.uri | https://doi.org/10.3906/kim-1910-35 | |
dc.description.abstract | An amphiphilic core/shell-type polymer-based drug carrier system (HPAE- PCL-b-MPEG), composed of hyperbranched poly(aminoester)-based polymer (HPAE) as the core building block and poly(ethylene glycol)-b-poly(epsilon-caprolactone) diblock polymers (MPEG-b-PCL) as the shell building block, was designed. The synthesized polymers were characterized with FTIR, H-1 NMR, C-13 NMR, and GPC analysis. Monodisperse HPAE-PCL-b-MPEG nanoparticles with dimensions of <200 nm and polydispersity index of <0.5 were prepared by nanoprecipitation method and characterized with SEM, particle size, and zeta potential analysis. 5-Fluorouracil was encapsulated within HPAE-PCL-b-MPEG nanoparticles. In vitro drug release profiles and cytotoxicity of blank and 5-fluorouracil-loaded nanoparticles were examined against the human colon cancer HCT116 cell line. All results suggest that HPAE-PCL-b-MPEG nanoparticles offer an alternative and effective drug nanocarrier system for drug delivery applications. | |
dc.language.iso | eng | |
dc.subject | Alkoloidler | |
dc.subject | Temel Bilimler | |
dc.subject | Mühendislik ve Teknoloji | |
dc.subject | Mühendislik, Bilişim ve Teknoloji (ENG) | |
dc.subject | Biyokimya | |
dc.subject | Kimya Mühendisliği ve Teknolojisi | |
dc.subject | Mühendislik | |
dc.subject | MÜHENDİSLİK, KİMYASAL | |
dc.subject | Temel Bilimler (SCI) | |
dc.subject | Kimya | |
dc.subject | KİMYA, MULTİDİSİPLİNER | |
dc.title | Design of an amphiphilic hyperbranched core/shell-type polymeric nanocarrier platform for drug delivery | |
dc.type | Makale | |
dc.relation.journal | TURKISH JOURNAL OF CHEMISTRY | |
dc.contributor.department | İstinye Üniversitesi , , | |
dc.identifier.volume | 44 | |
dc.identifier.issue | 2 | |
dc.identifier.startpage | 518 | |
dc.identifier.endpage | 534 | |
dc.contributor.firstauthorID | 2276546 | |