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dc.contributor.authorFethi, Meha
dc.contributor.authorIfaoui, Safa
dc.contributor.authorBellaaj, Ridha
dc.contributor.authorOuzari, Imene
dc.contributor.authorSALTOĞLU, Neşe
dc.contributor.authorKlibi, Naouel
dc.contributor.authorDziri, Raoudha
dc.contributor.authorKUŞKUCU, Mert Ahmet
dc.contributor.authorArfaoui, Amani
dc.date.accessioned2021-12-10T12:56:55Z
dc.date.available2021-12-10T12:56:55Z
dc.identifier.citationDziri R., KUŞKUCU M. A. , Arfaoui A., Fethi M., Ifaoui S., Bellaaj R., Ouzari I., SALTOĞLU N., Klibi N., "Whole Genome Sequencing of a Citrobacter freundii Strain Isolated from the Hospital Environment: An Extremely Multiresistant NDM-1 and VIM-48 Coproducing Isolate", MICROBIAL DRUG RESISTANCE, 2021
dc.identifier.issn1076-6294
dc.identifier.othervv_1032021
dc.identifier.otherav_e3c4b028-d610-4d60-81bc-07bd90fdbfc9
dc.identifier.urihttp://hdl.handle.net/20.500.12627/175062
dc.identifier.urihttps://doi.org/10.1089/mdr.2020.0417
dc.description.abstractCitrobacter freundii has acquired resistance to several antimicrobial drugs, including last-resort antibiotics affecting, therefore, clinical efficacy and causing high rates of mortality. In this study, we investigate the whole genome sequence of a carbapenem-resistant C. freundii strain isolated from the hospital environment in Tunisia. A total of 210 samples were taken using sterile swabs, from inanimate surfaces, medical devices, and care staff, during the period extended between March and April 2019. After the microbiological analysis of samples and antimicrobial susceptibility testing, only one strain identified as C. freundii showing resistance to carbapenems was selected for the whole genome sequencing. The genome analysis revealed a high-level resistance to most antibiotics. Interestingly, we have noted the coexistence of bla(NDM-1) and bla(VIM-48) metallo-beta-lactamase (MBL) encoding genes conferring resistance to carbapenems. Other beta-lactamases encoding genes have also been detected, including bla(TEM-1), bla(CMY-48), and bla(OXA-1). Moreover, genes conferring resistance to aminoglycoside [aac(3)-IId, ant(3 '')-Ia, aadA, aac(6 ')-Ib], macrolide [mph(A)], sulfonamide (sul1), trimethoprim (dfrA1), tetracycline [tet(D)], chloramphenicol [cat(B3)], rifamycin (arr-3), and quinolone (qnrB) have been revealed. The multi-locus sequence typing analysis showed that this isolate could not be assigned to an existing sequence type (ST), but it is almost identical to ST22. The plasmid investigation revealed the presence of five plasmids belonging to diverse incompatibility groups (IncFII, IncHI1A, IncHI1B, IncN, and IncX3). To the best of our knowledge, our findings report the first detection of NDM-1 and VIM-48 coproducing C. freundii in Tunisia and the second detection in the world of the bla(VIM-48).
dc.language.isoeng
dc.subjectDrug Guides
dc.subjectBULAŞICI HASTALIKLAR
dc.subjectİmmünoloji
dc.subjectYaşam Bilimleri (LIFE)
dc.subjectMikrobiyoloji
dc.subjectFARMAKOLOJİ VE ECZACILIK
dc.subjectFarmakoloji ve Toksikoloji
dc.subjectSağlık Bilimleri
dc.subjectEczacılık
dc.subjectTemel Eczacılık Bilimleri
dc.subjectInfectious Diseases
dc.subjectLife Sciences
dc.subjectHealth Sciences
dc.subjectImmunology
dc.subjectGeneral Pharmacology, Toxicology and Pharmaceutics
dc.subjectPharmacology, Toxicology and Pharmaceutics (miscellaneous)
dc.subjectPharmacology (medical)
dc.subjectPharmacy
dc.subjectYaşam Bilimleri
dc.subjectTemel Bilimler
dc.subjectGeneral Immunology and Microbiology
dc.subjectPharmacology
dc.titleWhole Genome Sequencing of a Citrobacter freundii Strain Isolated from the Hospital Environment: An Extremely Multiresistant NDM-1 and VIM-48 Coproducing Isolate
dc.typeMakale
dc.relation.journalMICROBIAL DRUG RESISTANCE
dc.contributor.departmentUniversité De Tunis El Manar , ,
dc.contributor.firstauthorID2703422


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