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dc.contributor.authorMesut, Burcu
dc.contributor.authorKazaz, Çağla
dc.contributor.authorÖzsoy, Yıldız
dc.contributor.authorOcak, Emine Meltem
dc.date.accessioned2021-12-10T13:03:06Z
dc.date.available2021-12-10T13:03:06Z
dc.date.issued2021
dc.identifier.citationKazaz Ç., Mesut B., Özsoy Y., Ocak E. M. , "Formulation development and evaluation of taste-masked atomoxetine hydrochloride orally disintegrating tablets (Odts)", Journal of Research in Pharmacy, cilt.25, sa.5, ss.715-727, 2021
dc.identifier.othervv_1032021
dc.identifier.otherav_eaaccbaf-0f49-493b-ad64-b2a6a7fd6847
dc.identifier.urihttp://hdl.handle.net/20.500.12627/175296
dc.identifier.urihttps://doi.org/10.29228/jrp.62
dc.description.abstract© 2021 Marmara University Press ISSN: 2630-6344.Atomoxetine hydrochloride is a selective norepinephrine reuptake inhibitor used for the treatment of attention deficit/hyperactivity disorder. Atomoxetine hydrochloride is available in the form of capsules and oral solutions, yet it has no orally disintegrating form due to its bitter taste. ODTs are formulated to disintegrate rapidly upon contact with saliva and enable oral administration without water or chewing and offer improved patient compliance and ease of administration. Appropriate taste masking has great importance for ODTs. In this study, developing a taste-masked ODT formulation containing atomoxetine hydrochloride produced using the wet granulation method was aimed. Formulations were designed by changing the granulation agent (Hydroxypropylmethylcellulose (HPMC), Gellan gum, Veegum, Polyethylene glycol (PEG) 20000P) and active substance to granulation agent ratio (1:2, 1:3, 1:4). Each formulation was tested physically and chemically. According to the results, it was concluded that Gellan gum is more appropriate for use in ODTs for taste masking.
dc.language.isoeng
dc.subjectDrug Guides
dc.subjectKlinik Tıp (MED)
dc.subjectLife Sciences
dc.subjectHealth Sciences
dc.subjectTemel Eczacılık Bilimleri
dc.subjectYaşam Bilimleri
dc.subjectTemel Bilimler
dc.subjectMultidisciplinary
dc.subjectPharmacology
dc.subjectGeneral Pharmacology, Toxicology and Pharmaceutics
dc.subjectPharmacology, Toxicology and Pharmaceutics (miscellaneous)
dc.subjectPharmacology (medical)
dc.subjectPharmacy
dc.subjectTemel Bilimler (SCI)
dc.subjectYaşam Bilimleri (LIFE)
dc.subjectDoğa Bilimleri Genel
dc.subjectFarmakoloji ve Toksikoloji
dc.subjectÇOK DİSİPLİNLİ BİLİMLER
dc.subjectFARMAKOLOJİ VE ECZACILIK
dc.subjectSağlık Bilimleri
dc.subjectEczacılık
dc.titleFormulation development and evaluation of taste-masked atomoxetine hydrochloride orally disintegrating tablets (Odts)
dc.typeMakale
dc.relation.journalJournal of Research in Pharmacy
dc.contributor.departmentAli Raif Pharmaceutical Corporation , ,
dc.identifier.volume25
dc.identifier.issue5
dc.identifier.startpage715
dc.identifier.endpage727
dc.contributor.firstauthorID2741025


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