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dc.contributor.authorSayin, H. Umit
dc.date.accessioned2021-03-02T23:21:23Z
dc.date.available2021-03-02T23:21:23Z
dc.date.issued2017
dc.identifier.citationSayin H. U. , "A Bio-Electrical Tornado in The Hippocampus: Mechanisms of Temporal Lobe Epilepsy", NEUROQUANTOLOGY, cilt.15, sa.1, ss.92-103, 2017
dc.identifier.issn1303-5150
dc.identifier.othervv_1032021
dc.identifier.otherav_11f2c5e2-ea32-46da-afeb-16c9950292dd
dc.identifier.urihttp://hdl.handle.net/20.500.12627/17532
dc.identifier.urihttps://doi.org/10.14704/nq.2017.15.1.1014
dc.description.abstractThis review summarizes the structural and electrophysiological changes in the epileptic hippocampus in various animal models of epilepsy. Tornado hypothesis of epileptic hippocampus, states that there are many progressive detrimental changes in the hippocampus of the epileptic rats. PTZ, PTZ kindling, pilocarpine, electrical kindling, kainic acid, hyperthermia and in vitro models are taken as primary animal epilepsy models in this review. Paired pulse inhibition and GABAergic transmission is decreased in dentate gyrus (DG), CA3 and CA1 regions of the epileptic hippocampus. There is interneuron loss in the hilus, DG and CA3, while excitatory input from perforant path (PP) is increased and this is fed into the CA3 area by mossy fibers (MF) which have excessive sprouting that forms novel recurrent synapses with the pyramidal cells of CA3. Gate function of DG is either impaired or lost. CA3 area of hippocampus becomes an epileptic focus and sends ictal discharges. These ictal discharges are carried into CA1 by Schaffer collaterals and then into entorhinal cortex (EC). The input from EC is amplified in the hippocampal circuitry which is fed into hippocampus from EC into DG again successively. Thus, a weak electrical input into the hippocampal formation results in an amplified signal back into EC. Since the basic ultrastructural and electrophysiological feed-back control mechanisms are impaired, this electrical tornado cannot be compensated for and an epileptic amplified ictal discharge spreads to the limbic system and other adjacent structures of the brain. Eventually the hippocampal circuitry, that has developed a vicious circle, becomes a bioelectrical amplifier which triggers an electrical tornado, under certain bio-chemical conditions.
dc.language.isoeng
dc.subjectSinirbilim ve Davranış
dc.subjectNEUROSCIENCES
dc.subjectTemel Bilimler
dc.subjectYaşam Bilimleri
dc.subjectYaşam Bilimleri (LIFE)
dc.titleA Bio-Electrical Tornado in The Hippocampus: Mechanisms of Temporal Lobe Epilepsy
dc.typeMakale
dc.relation.journalNEUROQUANTOLOGY
dc.contributor.departmentİstanbul Üniversitesi , ,
dc.identifier.volume15
dc.identifier.issue1
dc.identifier.startpage92
dc.identifier.endpage103
dc.contributor.firstauthorID240950


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