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The effects of prochloraz on the levels of nuclear receptor genes expressions and global DNA methylation in human prostate carcinoma cells

dc.contributor.authorOzden, Sibel
dc.contributor.authorKaraman, Ecem Fatma
dc.contributor.authorDogan, Esma
dc.contributor.authorAlga, Dilara
dc.date.accessioned2021-12-10T13:07:54Z
dc.date.available2021-12-10T13:07:54Z
dc.date.issued2021
dc.identifier.citationKaraman E. F. , Dogan E., Alga D., Ozden S., "The effects of prochloraz on the levels of nuclear receptor genes expressions and global DNA methylation in human prostate carcinoma cells", ISTANBUL JOURNAL OF PHARMACY, cilt.51, sa.2, ss.191-197, 2021
dc.identifier.othervv_1032021
dc.identifier.otherav_f0291fd1-6eaf-4fc8-979e-3984a7027b96
dc.identifier.urihttp://hdl.handle.net/20.500.12627/175466
dc.identifier.urihttps://doi.org/10.26650/istanbuljpharm.2021.850791
dc.description.abstractBackground and Aims: Prochloraz (PCZ) is an imidazole fungicide which is used in agriculture and gardening. PCZ, with endocrine disrupting effect, disrupts reproductive and developmental functions. Previously, the effects of PCZ on the estrogen and androgen receptors have been shown in vitro and in vivo. Because of endocrine disrupting effects, PCZ could influence nuclear receptors which acted as ER and AR antagonists. Besides, PCZ has been thought to have no genotoxic effects. Therefore, we aimed to investigate possible effects of PCZ on nuclear receptor genes and epigenetic mechanisms in human prostate carcinoma (PC-3) cells.
dc.language.isoeng
dc.subjectPharmacology (medical)
dc.subjectFARMAKOLOJİ VE ECZACILIK
dc.subjectFarmakoloji ve Toksikoloji
dc.subjectYaşam Bilimleri (LIFE)
dc.subjectSağlık Bilimleri
dc.subjectEczacılık
dc.subjectTemel Eczacılık Bilimleri
dc.subjectYaşam Bilimleri
dc.subjectTemel Bilimler
dc.subjectPharmacology
dc.subjectGeneral Pharmacology, Toxicology and Pharmaceutics
dc.subjectPharmacology, Toxicology and Pharmaceutics (miscellaneous)
dc.subjectPharmacy
dc.subjectDrug Guides
dc.subjectLife Sciences
dc.subjectHealth Sciences
dc.titleThe effects of prochloraz on the levels of nuclear receptor genes expressions and global DNA methylation in human prostate carcinoma cells
dc.typeMakale
dc.relation.journalISTANBUL JOURNAL OF PHARMACY
dc.contributor.departmentBiruni Üniversitesi , ,
dc.identifier.volume51
dc.identifier.issue2
dc.identifier.startpage191
dc.identifier.endpage197
dc.contributor.firstauthorID2721679


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