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dc.contributor.authorBuhur Pirimoglu, Meltem
dc.contributor.authorDoğan Demir, Ayşegül
dc.contributor.authorÇakir, Fatma Betül
dc.contributor.authorTorun, Emel
dc.contributor.authorErgen, Hayriye Arzu
dc.contributor.authorUstabas Kahraman, Feyza
dc.date.accessioned2021-12-10T13:12:48Z
dc.date.available2021-12-10T13:12:48Z
dc.date.issued2021
dc.identifier.citationUstabas Kahraman F., Çakir F. B. , Buhur Pirimoglu M., Torun E., Ergen H. A. , Doğan Demir A., "Association of Myeloperoxidase Gene Polymorphism With Iron Deficiency Anemia in Turkish Children.", Journal of pediatric hematology/oncology, cilt.43, sa.7, 2021
dc.identifier.issn1077-4114
dc.identifier.otherav_f5b8103d-2fab-44db-88a3-42ff3a65b4e6
dc.identifier.othervv_1032021
dc.identifier.urihttp://hdl.handle.net/20.500.12627/175657
dc.identifier.urihttps://doi.org/10.1097/mph.0000000000002125
dc.description.abstractThis study was performed to investigate the gene polymorphisms of the myeloperoxidase (MPO) enzyme and to determine whether MPO gene polymorphisms influence the response to iron therapy in pediatric patients with iron deficiency anemia (IDA). In this case-control study, 50 Turkish children with IDA and 50 healthy controls were enrolled. Three MPO gene alleles were selected for genotyping in the study: GG, AG, and AA. The relationships of alleles with IDA were analyzed and compared in patients and controls. Pretreatment and posttreatment laboratory parameters and gene polymorphisms were compared in the patient group. There was a significant difference between patients with IDA and controls regarding genotype frequencies of the AA, GG, and AG alleles (P=0.005). However, the AG allele was found to be associated with variations in hemoglobin, red blood cell, hematocrit, mean corpuscular volumes, and mean corpuscular Hb concentrations levels. The frequency of AA, GG, and AG alleles of the MPO gene was potentially associated with changes in iron metabolism and the AG allele led to variations in various hemogram parameters.
dc.language.isoeng
dc.subjectYaşam Bilimleri
dc.subjectTemel Bilimler
dc.subjectMultidisciplinary
dc.subjectTıp
dc.subjectSağlık Bilimleri
dc.subjectÇOK DİSİPLİNLİ BİLİMLER
dc.subjectDoğa Bilimleri Genel
dc.subjectKlinik Tıp
dc.subjectYaşam Bilimleri (LIFE)
dc.subjectTemel Bilimler (SCI)
dc.subjectKlinik Tıp (MED)
dc.titleAssociation of Myeloperoxidase Gene Polymorphism With Iron Deficiency Anemia in Turkish Children.
dc.typeMakale
dc.relation.journalJournal of pediatric hematology/oncology
dc.contributor.department, ,
dc.identifier.volume43
dc.identifier.issue7
dc.contributor.firstauthorID2741424


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