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dc.contributor.authorVeliev, Aynur
dc.contributor.authorNakipoğlu, Yaşar
dc.date.accessioned2022-02-18T09:07:15Z
dc.date.available2022-02-18T09:07:15Z
dc.date.issued2022
dc.identifier.citationVeliev A., Nakipoğlu Y., "Investigation of Staphylococcus lugdunensis and Selected Coagulase Negative Staphylococci Isolated from Blood Culture bottles and Determination of their Sensitivities to Antibiotics", Pakistan Journal Of Medical Sciences, cilt.38, sa.3, ss.657-662, 2022
dc.identifier.issn1682-024X
dc.identifier.othervv_1032021
dc.identifier.otherav_1b3dc191-a70a-461a-9739-33672b8a1963
dc.identifier.urihttp://hdl.handle.net/20.500.12627/176555
dc.identifier.urihttps://avesis.istanbul.edu.tr/api/publication/1b3dc191-a70a-461a-9739-33672b8a1963/file
dc.identifier.urihttps://doi.org/10.12669/pjms.38.3.4738
dc.description.abstractObjectives:Coagulase-negative staphylococci (CNS) are commensal skin microbiota but may also cause septicemia, endocarditis, and systemic infections. Staphylococcus lugdunensis, is a member of CNS, ​​but their antibiotic susceptibility test should be evaluated as Staphylococcus aureus not as CNS. We aimed to investigate S.lugdunensis and selected CNS strains by simple biochemical method and determination of their susceptibilities to antibiotics.Methods:A total of 251 CNS isolates were collected from blood culture bottles sent to Istanbul Faculty of Medicine Department of Medical Microbiology, between 2018 and 2019. PYR (pyrrolidonyl arylamidase) and ODC (ornithine decarboxylase) tests were performed on total of CNS isolates and API Staph was used for identification of the isolates giving positive result in both or either of these two tests. Disk diffusion method was used for the determination of antibiotic susceptibility of the isolates. S. aureus ATCC 25923 and S S.lugdunensis ATCC® 49576 strains were used as quality control strains in disc diffusion method, and biochemical tests, respectively.Results:Twenty three out of 251 CNS isolates were positive in each or both of PYR and ODC tests. We detected the first S.lugdunensis isolate from eye vitreous fluid of patient developed a postoperative endophthalmitis in Turkey. This isolate gave dual positive with ODC, PYR, and API Staph. Other 22 CNS isolates were from blood cultures and distributed as follows; 14 Staphylococcus haemolyticus and three Staphylococcus chromogenes isolates were PYR positive and ODC negative and five Staphylococcus epidermidis isolates were ODC positive and PYR negative. All isolates except S.lugdunensis were resistant to penicillin (95.7%) and 20 (87.0%) isolates were found to be methicillin resistant.Conclusions:ODC and PYR are cost effective tests and easily applicable for accurate identification of S.lugdunensis, and eliminating of opportinistic pathogens such as S. epidermidis, S. haemolyticus, and S. chromogenes from other CNS species in postoperative endophthalmitis and pateints with malignancies. Linezolid was very effective (100%) on four selected CNS species.
dc.language.isoeng
dc.subjectTemel Bilimler
dc.subjectDoğa Bilimleri Genel
dc.subjectÇOK DİSİPLİNLİ BİLİMLER
dc.subjectMultidisciplinary
dc.subjectTemel Bilimler (SCI)
dc.titleInvestigation of Staphylococcus lugdunensis and Selected Coagulase Negative Staphylococci Isolated from Blood Culture bottles and Determination of their Sensitivities to Antibiotics
dc.typeMakale
dc.relation.journalPakistan Journal Of Medical Sciences
dc.contributor.departmentİstanbul Üniversitesi , İstanbul Tıp Fakültesi , Temel Tıp Bilimleri Bölümü
dc.identifier.volume38
dc.identifier.issue3
dc.identifier.startpage657
dc.identifier.endpage662
dc.contributor.firstauthorID3389523


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