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dc.contributor.authorYüceer, Hande
dc.contributor.authorTüzün, Erdem
dc.date.accessioned2021-03-02T15:47:12Z
dc.date.available2021-03-02T15:47:12Z
dc.identifier.citationYüceer H., Tüzün E., Neuro-Behçet’s Disease: Epidemiology and Genetics, "Neuro-Behçet's Disease", Erdem Tüzün,Murat Kürtüncü, Editör, Springer-Verlag , London, ss.1-16, 2021
dc.identifier.otherav_8a24c9e9-41f9-45ec-a118-0b7d387ab10b
dc.identifier.othervv_1032021
dc.identifier.urihttp://hdl.handle.net/20.500.12627/1768
dc.identifier.urihttps://link.springer.com/chapter/10.1007/978-3-030-55273-2_1
dc.description.abstractBehçet’s disease (BD) is a chronic inflammatory disorder affecting multiple systems in the body. Neuro-Behçet’s disease (NBD) is the neurological manifestation of BD. It usually occurs late in the disease and tends to affect 10–30% of BD patients. The neurological symptoms may include cerebral thrombosis in the arterial or venous systems, meningoencephalitis, demyelination, memory loss, and behavioral changes. Although BD cases have been reported from all over the world, it is more common in the geographical regions on the historic Silk Route. The highest prevalence of the disease is in Turkey. It mostly affects individuals between 20 and 40years of age and affects men and women equally. BD etiology has not been well understood yet, but various genetic, environmental, and immunological factors are thought to play a role. Although the human leukocyte antigen (HLA)-B51 has long been suggested to be the dominant predisposing factor in BD, the non-major histocompatibility complex (MHC) class I genes have been associated with BD susceptibility as well. The genome-wide association studies (GWAS) reported various single-nucleotide polymorphism of certain genes in BD. Additionally, targeted next-generation sequencing methods have demonstrated non-synonymous variants (NSVs). The epigenetics (interspersed repetitive sequences, miRNAs) of BD and NBD have also been of interest to the researchers lately. Even though the studies primarily focus on BD rather than NBD, the data gathered for BD has been expected to be compatible with NBD etiopathogenesis. Further NBD-oriented epidemiologic, genetic, and epigenetic studies are needed to enlighten the disease etiology and to detect differential NBD biomarkers.
dc.language.isoeng
dc.publisherSpringer-Verlag
dc.subjectFundamentals and Skills
dc.subjectAssessment and Diagnosis
dc.subjectInternal Medicine
dc.subjectPathophysiology
dc.subjectGeneral Health Professions
dc.subjectHealth Sciences
dc.subjectLife Sciences
dc.subjectNeurology (clinical)
dc.subjectFamily Practice
dc.subjectGeneral Medicine
dc.subjectMedicine (miscellaneous)
dc.subjectKlinik Tıp (MED)
dc.subjectKlinik Tıp
dc.subjectKLİNİK NEUROLOJİ
dc.subjectTIP, GENEL & İÇECEK
dc.subjectTıp
dc.subjectSağlık Bilimleri
dc.subjectDahili Tıp Bilimleri
dc.subjectNöroloji
dc.subjectNeurology
dc.titleNeuro-Behçet's Disease
dc.typeKitapta Bölüm
dc.contributor.departmentİstanbul Üniversitesi , Deneysel Tıp Araştırma Enstitüsü , Sinirbilim Ad
dc.contributor.firstauthorID2497102


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