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dc.contributor.authorKiykim, Ertugrul
dc.contributor.authorBakir, Alev
dc.contributor.authorIkitimur, Baris
dc.contributor.authorTrabulus, Sinan
dc.contributor.authorSeyahi, Nurhan
dc.contributor.authorDincer, Mevlut Tamer
dc.contributor.authorOzcan, Seyda Gul
dc.date.accessioned2022-02-18T09:24:28Z
dc.date.available2022-02-18T09:24:28Z
dc.identifier.citationDincer M. T. , Ozcan S. G. , Ikitimur B., Kiykim E., Bakir A., Trabulus S., Seyahi N., "Blood Pressure Variability in Fabry Disease Patients", NEPHRON, 2021
dc.identifier.issn1660-8151
dc.identifier.othervv_1032021
dc.identifier.otherav_379bf958-c03f-412d-b7c4-fed6a4204186
dc.identifier.urihttp://hdl.handle.net/20.500.12627/177145
dc.identifier.urihttps://doi.org/10.1159/000520699
dc.description.abstractIntroduction: Fabry disease is a rare metabolic, multisystemic, and X-linked lysosomal storage disorder. The involvement of the autonomic nervous system is well defined; however, data on the variability of the blood pressure (BP) and heart rate in Fabry disease are largely missing. In this study, we aimed to examine the circadian variations of BP and heart rate variability in Fabry disease patients. Methods: We recruited 31 consecutive adult (age >18 years) Fabry disease patients (16 males and 15 females) who were regularly followed up in our outpatient clinic between July 2019 and March 2020. We performed ambulatory blood pressure monitoring and echocardiography in all patients. We used standard deviation (SD), coefficient of variation (CV), and average real variability as the measures of variability. We constructed 2 control groups for propensity score matching using age, sex, and eGFR parameters in the first group and adding antihypertensive drug use to the above parameters in the second group. Results: All BP measurements were significantly lower in the FD group compared to that of the control groups, except the nighttime systolic BP. Regarding nondipping and reverse dipping statuses, FD patients and controls were similar. We found that none of the BP variability measures were higher in FD patients. Regarding heart rate variability data, both the nighttime SD and CV were significantly lower in FD patients compared to those of the controls. Conclusion: A decrease in heart rate variability, rather than an increase in BP variability, might be an early marker of autonomic involvement in FD.
dc.language.isoeng
dc.subjectNefroloji
dc.subjectNephrology
dc.subjectUrology
dc.subjectHealth Sciences
dc.subjectDahili Tıp Bilimleri
dc.subjectİç Hastalıkları
dc.subjectSağlık Bilimleri
dc.subjectTıp
dc.subjectKlinik Tıp (MED)
dc.subjectKlinik Tıp
dc.subjectÜROLOJİ VE NEFROLOJİ
dc.titleBlood Pressure Variability in Fabry Disease Patients
dc.typeMakale
dc.relation.journalNEPHRON
dc.contributor.departmentIstanbul University - Cerrahpasa , ,
dc.contributor.firstauthorID3083426


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