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dc.contributor.authorUlutin, T
dc.contributor.authorOzaydin, A
dc.contributor.authorGultepe, M
dc.contributor.authorOnaran, I
dc.contributor.authorTunckale, Aydın
dc.contributor.authorAkbas, F
dc.date.accessioned2021-03-02T23:24:35Z
dc.date.available2021-03-02T23:24:35Z
dc.date.issued2000
dc.identifier.citationOnaran I., Ozaydin A., Akbas F., Gultepe M., Tunckale A., Ulutin T., "Are individuals with glutathione S-transferase GSTT1 null genotype more susceptible to in vitro oxidative damage?", JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A-CURRENT ISSUES, cilt.59, sa.1, ss.15-26, 2000
dc.identifier.issn1528-7394
dc.identifier.otherav_123ec3b3-3eae-4c10-a1b6-80fca9ebedba
dc.identifier.othervv_1032021
dc.identifier.urihttp://hdl.handle.net/20.500.12627/17723
dc.identifier.urihttps://doi.org/10.1080/009841000157041
dc.description.abstractRecent epidemiological studies proposed that glutathione S-transferase (GST) Ti null genotype was correlated with an increased susceptibility to diseases associated with oxidative stress, including cancer. A comparative study using erythrocytes from individuals with GSTT1 null genotype was carried out to determine how resistance to oxidative stress is affected by lack of this gene, and whether the CST status of a person is an important factor in risk toward oxidant chemicals. Malondialdehyde and carbonyl levels and fluorescence and chemiluminescence formation were used as biomarkers of oxidative stress in erythrocytes exposed in vitro to cumene hydroperoxide (CumOOH), an oxidizing agent. When peroxidation-dependent changes in these parameters were compared between GSTT1 null genotype and controls, who are both GSTM1 and GSTT1 positive, no significant differences were found between the two genotypes, although the erythrocytes of the GSTT1 null group had lower GSTT1 activity toward CumOOH. Our results indicate that erythrocytes from individuals with GSTT1 null genotype are not abnormally susceptible to CumOOH-induced oxidant challenge.
dc.language.isoeng
dc.subjectSosyal Bilimler Genel
dc.subjectSosyal Bilimler (SOC)
dc.subjectTOKSİKOLOJİ
dc.subjectFarmakoloji ve Toksikoloji
dc.subjectYaşam Bilimleri (LIFE)
dc.subjectSağlık Bilimleri
dc.subjectEczacılık
dc.subjectMeslek Bilimleri
dc.subjectFarmasötik Toksikoloji
dc.subjectSosyal ve Beşeri Bilimler
dc.subjectSosyoloji
dc.subjectTarımsal Bilimler
dc.subjectÇevre Mühendisliği
dc.subjectÇevre / Ekoloji
dc.subjectTemel Bilimler
dc.subjectMühendislik ve Teknoloji
dc.subjectYaşam Bilimleri
dc.subjectTarım ve Çevre Bilimleri (AGE)
dc.subjectKAMU, ÇEVRE VE İŞ SAĞLIĞI
dc.subjectÇEVRE BİLİMLERİ
dc.titleAre individuals with glutathione S-transferase GSTT1 null genotype more susceptible to in vitro oxidative damage?
dc.typeMakale
dc.relation.journalJOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A-CURRENT ISSUES
dc.contributor.departmentBezmiâlem Vakıf Üniversitesi , ,
dc.identifier.volume59
dc.identifier.issue1
dc.identifier.startpage15
dc.identifier.endpage26
dc.contributor.firstauthorID48978


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