dc.contributor.author | Mat, Mehmet Cem | |
dc.contributor.author | Sayman, Haluk | |
dc.contributor.author | Sönmezoğlu, Kerim | |
dc.contributor.author | Erdil, T.Yusuf | |
dc.contributor.author | Ozkara, Hamdi | |
dc.contributor.author | Demir, Mustafa | |
dc.contributor.author | Kabasakal, Levant | |
dc.contributor.author | Yardı, Ö.Fehmi | |
dc.contributor.author | Solanki, K | |
dc.contributor.author | Britton, KE | |
dc.date.accessioned | 2021-03-02T23:24:37Z | |
dc.date.available | 2021-03-02T23:24:37Z | |
dc.date.issued | 1998 | |
dc.identifier.citation | Sönmezoğlu K., Erdil T., Demir M., Sayman H., Kabasakal L., Yardı Ö., Ozkara H., Mat M. C. , Solanki K., Britton K., "Evaluation of renal function in low-dose cyclosporine-treated patients using technetium-99m diaminocyclohexane: a cationic tubular excretion agent", EUROPEAN JOURNAL OF NUCLEAR MEDICINE, cilt.25, sa.12, ss.1630-1636, 1998 | |
dc.identifier.issn | 0340-6997 | |
dc.identifier.other | vv_1032021 | |
dc.identifier.other | av_123ff507-e7bc-47c7-be05-fc332080b8ff | |
dc.identifier.uri | http://hdl.handle.net/20.500.12627/17726 | |
dc.identifier.uri | https://doi.org/10.1007/s002590050341 | |
dc.description.abstract | Technetium-99m diaminocyclohexane (DACH) is a new tubular agent excreted via a cationic transport mechanism, like cyclosporine-A (CsA), It is expected that Tc-99m-DACH will permit effective assessment of tubular function in CsA-treated patients. To establish the pharmacokinetic characteristics of Tc-99m-DACH and to ascertain whether this new agent is useful in CsA-treated patients, 11 healthy volunteers and 15 CsA-treated patients underwent renal imaging and clearance studies using Tc-99m-DACH and chromium-51 ethylene diamine tetra-acetic acid (EDTA). 99mTc-DACH yielded satisfactory dynamic renal images in all participants. The mean plasma clearance of Tc-99m-DACH was significantly greater than that of Cr-51-EDTA In volunteers (109.4+/-19.7 ml/min versus 86.6+/-13.7 ml/min, P<0.05). However, the urinary excretion of 99mTc-DACH at 90 min was significantly lower than that of Cr-51-EDTA (46.1%+/-9.3% versus 53.1%+/-8.6%, P<0.05), most probably due to its partial parenchymal retention. The elimination half-life of Tc-99m-DACH was significantly increased in CsA-treated patients in comparison to volunteers, and consequently the plasma clearance values were significantly suppressed in these patients, in contrast to Cr-51-EDTA and endogenous creatinine clearance values. In conclusion, our findings indicate that Tc-99m-DACH, as a sensitive marker of cationic tubular function, could be used to monitor renal haemodynamics in patients receiving CsA treatment. | |
dc.language.iso | eng | |
dc.subject | Tıp | |
dc.subject | Dahili Tıp Bilimleri | |
dc.subject | Nükleer Tıp | |
dc.subject | Sağlık Bilimleri | |
dc.subject | Klinik Tıp (MED) | |
dc.subject | Klinik Tıp | |
dc.subject | RADYOLOJİ, NÜKLEER TIP ve MEDİKAL GÖRÜNTÜLEME | |
dc.title | Evaluation of renal function in low-dose cyclosporine-treated patients using technetium-99m diaminocyclohexane: a cationic tubular excretion agent | |
dc.type | Makale | |
dc.relation.journal | EUROPEAN JOURNAL OF NUCLEAR MEDICINE | |
dc.contributor.department | İstanbul Üniversitesi , , | |
dc.identifier.volume | 25 | |
dc.identifier.issue | 12 | |
dc.identifier.startpage | 1630 | |
dc.identifier.endpage | 1636 | |
dc.contributor.firstauthorID | 26456 | |