Discovery of a genetic module essential for assigning left-right asymmetry in humans and ancestral vertebrates

Author
Schoen, Patric
Louvel, Guillaume
Anujan, Priyanka
Ravi, Vydianathan
Bonnard, Carine
Moutton, Sebastien
Fradin, Melanie
Colin, Estelle
Megarbane, Andre
Daou, Linda
Chehab, Ghassan
Di Filippo, Sylvie
Rooryck, Caroline
Deleuze, Jean-Francois
Boland, Anne
Arribard, Nicolas
Eker, Rukiye
Tohari, Sumanty
Ng, Alvin Yu-Jin
Rio, Marlene
Lim, Chun Teck
Eisenhaber, Birgit
Eisenhaber, Frank
Venkatesh, Byrappa
Amiel, Jeanne
Crollius, Hugues Roest
Gordon, Christopher T.
Gossler, Achim
Roy, Sudipto
Attie-Bitach, Tania
Blum, Martin
Bouvagnet, Patrice
Reversade, Bruno
Szenker-Ravi, Emmanuelle
Ott, Tim
Khatoo, Muznah
de Bellaing, Anne Moreau
Goh, Wei Xuan
Chong, Yan Ling
Beckers, Anja
Kannesan, Darshini
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Abstract
Phylogenomic and genetic analyses identify an ancestral module of genes expressed specifically in ciliated left-right organizer tissue and required for left-right axis specification in humans and certain vertebrates.
URI
http://hdl.handle.net/20.500.12627/178988
https://doi.org/10.1038/s41588-021-00970-4
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