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Antimalarial agents from plants - II. Decursivine, a new antimalarial indole alkaloid from Rhaphidophora decursiva

dc.contributor.authorFong, HHS
dc.contributor.authorZhang, HJ
dc.contributor.authorQiu, SX
dc.contributor.authorTamez, P
dc.contributor.authorTan, GT
dc.contributor.authorAydogmus, Z
dc.contributor.authorVan Hung, N
dc.contributor.authorCuong, NM
dc.contributor.authorAngerhofer, C
dc.contributor.authorSoejarto, DD
dc.contributor.authorPezzuto, JM
dc.date.accessioned2022-02-18T10:24:23Z
dc.date.available2022-02-18T10:24:23Z
dc.date.issued2002
dc.identifier.citationZhang H., Qiu S., Tamez P., Tan G., Aydogmus Z., Van Hung N., Cuong N., Angerhofer C., Soejarto D., Pezzuto J., et al., "Antimalarial agents from plants - II. Decursivine, a new antimalarial indole alkaloid from Rhaphidophora decursiva", PHARMACEUTICAL BIOLOGY, cilt.40, sa.3, ss.221-224, 2002
dc.identifier.issn1388-0209
dc.identifier.otherav_9932eafd-3c9f-4c6d-af40-d50f3f781a29
dc.identifier.othervv_1032021
dc.identifier.urihttp://hdl.handle.net/20.500.12627/179178
dc.identifier.urihttps://doi.org/10.1076/phbi.40.3.221.5832
dc.description.abstractAntimalarial bioassay-directed fractionation led to the isolation of a new active indole alkaloid, decursivine (1), from the leaves and stems of Rhaphidophora decursiva Schott (Araceae). In addition, a leaf sample yielded the structurally-related compound serotobenine (2), previously reported from a taxonomically unrelated family, which was not active against Plasmodium falciparum. The structure of 1 was elucidated by spectroscopic means, and its antimalarial activity was observed with IC50 values of 3.93 and 4.41 mug/ml against the D6 and W2 clones of Plasmodium falciparum, respectively.
dc.language.isoeng
dc.subjectMedical Laboratory Technology
dc.subjectPharmacy
dc.subjectDrug Guides
dc.subjectSmall Animals
dc.subjectLife Sciences
dc.subjectHealth Sciences
dc.subjectPharmacology, Toxicology and Pharmaceutics (miscellaneous)
dc.subjectBİTKİ BİLİMLERİ
dc.subjectBitki ve Hayvan Bilimleri
dc.subjectTarım ve Çevre Bilimleri (AGE)
dc.subjectTIBBİ LABORATUVAR TEKNOLOJİSİ
dc.subjectKlinik Tıp
dc.subjectKlinik Tıp (MED)
dc.subjectFARMAKOLOJİ VE ECZACILIK
dc.subjectFarmakoloji ve Toksikoloji
dc.subjectYaşam Bilimleri (LIFE)
dc.subjectTıp
dc.subjectSağlık Bilimleri
dc.subjectEczacılık
dc.subjectTemel Eczacılık Bilimleri
dc.subjectTarımsal Bilimler
dc.subjectZiraat
dc.subjectBitki Koruma
dc.subjectFitopatoloji
dc.subjectYaşam Bilimleri
dc.subjectTemel Bilimler
dc.subjectPlant Science
dc.subjectPharmacology
dc.subjectGeneral Pharmacology, Toxicology and Pharmaceutics
dc.subjectPharmacology (medical)
dc.titleAntimalarial agents from plants - II. Decursivine, a new antimalarial indole alkaloid from Rhaphidophora decursiva
dc.typeMakale
dc.relation.journalPHARMACEUTICAL BIOLOGY
dc.contributor.department, ,
dc.identifier.volume40
dc.identifier.issue3
dc.identifier.startpage221
dc.identifier.endpage224
dc.contributor.firstauthorID3371985


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