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dc.contributor.authorSANTOS, C.
dc.contributor.authorSERRULLA RECH, F.
dc.contributor.authorPEREZ CARCELES, M. D.
dc.contributor.authorCARRACEDO, A.
dc.contributor.authorSCHNEIDER, P. M.
dc.contributor.authorLAREU, M. V.
dc.contributor.authorBulbul, O.
dc.contributor.authorPHILLIPS, C.
dc.contributor.authorFREIRE ARADAS, A.
dc.contributor.authorKRIEGEL, A. K.
dc.contributor.authorFONDEVILA, M.
dc.date.accessioned2021-03-03T07:34:44Z
dc.date.available2021-03-03T07:34:44Z
dc.date.issued2013
dc.identifier.citationPHILLIPS C., FREIRE ARADAS A., KRIEGEL A. K. , FONDEVILA M., Bulbul O., SANTOS C., SERRULLA RECH F., PEREZ CARCELES M. D. , CARRACEDO A., SCHNEIDER P. M. , et al., "Eurasiaplex: A forensic SNP assay for differentiating European and South Asian ancestries", FORENSIC SCIENCE INTERNATIONAL-GENETICS, cilt.7, sa.3, ss.359-366, 2013
dc.identifier.issn1872-4973
dc.identifier.otherav_12b08633-1142-4d3a-be4a-ac6f54f3dd4b
dc.identifier.othervv_1032021
dc.identifier.urihttp://hdl.handle.net/20.500.12627/18005
dc.identifier.urihttps://doi.org/10.1016/j.fsigen.2013.02.010
dc.description.abstractWe have selected a set of single nucleotide polymorphisms (SNPs) with the specific aim of differentiating European and South Asian ancestries. The SNPs were combined into a 23-plex SNaPshot primer extension assay: Eurasiaplex, designed to complement an existing 34-plex forensic ancestry test with both marker sets occupying well-spaced genomic positions, enabling their combination as single profile submissions to the Bayesian Snipper forensic ancestry inference system. We analyzed the ability of Eurasiaplex plus 34plex SNPs to assign ancestry to a total 1648 profiles from 16 European, 7 Middle East, 13 Central-South Asian and 21 East Asian populations. Ancestry assignment likelihoods were estimated from Snipper using training sets of five-group data (three Eurasian groups, East Asian and African genotypes) and four-group data (Middle East genotypes removed). Five-group differentiations gave assignment success of 91% for NW European populations, 72% for Middle East populations and 39% for Central-South Asian populations, indicating Middle East individuals are not reliably differentiated from either Europeans or Central-South Asians. Four-group differentiations provided markedly improved assignment success rates of 97% for most continental Europeans tested (excluding Turkish and Adygei at the far eastern edge of Europe) and 95% for Central-South Asians, despite applying a probability threshold for the highest likelihood ratio above '100 times more likely'. As part of the assessment of the sensitivity of Eurasiaplex to analyze challenging forensic material we detail Eurasiaplex and 34-plex SNP typing to infer ancestry of a cranium recovered from the sea, achieving 82% SNP genotype completeness. Therefore, Eurasiaplex provides an informative and forensically robust approach to the differentiation of European and South Asian ancestries amongst Eurasian populations. (C) 2013 Elsevier Ireland Ltd. All rights reserved.
dc.language.isoeng
dc.subjectYaşam Bilimleri
dc.subjectGENETİK VE HAYAT
dc.subjectMoleküler Biyoloji ve Genetik
dc.subjectYaşam Bilimleri (LIFE)
dc.subjectTIP, YASAL
dc.subjectKlinik Tıp
dc.subjectKlinik Tıp (MED)
dc.subjectTıp
dc.subjectSağlık Bilimleri
dc.subjectDahili Tıp Bilimleri
dc.subjectAdli Tıp
dc.subjectTıbbi Genetik
dc.subjectMoleküler Biyoloji ve Genetik
dc.subjectTemel Bilimler
dc.titleEurasiaplex: A forensic SNP assay for differentiating European and South Asian ancestries
dc.typeMakale
dc.relation.journalFORENSIC SCIENCE INTERNATIONAL-GENETICS
dc.contributor.departmentUniversity of Santiago De Compostela , ,
dc.identifier.volume7
dc.identifier.issue3
dc.identifier.startpage359
dc.identifier.endpage366
dc.contributor.firstauthorID84385


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