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dc.contributor.authorKecel-Gunduz, Serda
dc.contributor.authorOzdemir, Burak
dc.contributor.authorBudama-Kilinc, Yasemin
dc.contributor.authorBicak, Bilge
dc.date.accessioned2022-07-04T11:58:37Z
dc.date.available2022-07-04T11:58:37Z
dc.identifier.citationBicak B., Kecel-Gunduz S., Budama-Kilinc Y., Ozdemir B., "Molecular docking studies of YKT tripeptide and drug delivery system with poly(epsilon-caprolactone) nanoparticles", ARCHIV DER PHARMAZIE, 2022
dc.identifier.issn0365-6233
dc.identifier.othervv_1032021
dc.identifier.otherav_072ea495-ea70-4137-8647-72cd36055e99
dc.identifier.urihttp://hdl.handle.net/20.500.12627/181483
dc.identifier.urihttps://doi.org/10.1002/ardp.202100437
dc.description.abstractTyrosyllysylthreonine (YKT) is a peptide structure that contains three different amino acids in its structure and has anticancer properties. The main purpose of this study is to reveal the structural interactions of the peptide and to increase the efficiency of the peptide with nanoformulation. For these purposes, YKT-loaded poly(epsilon-caprolactone) (PCL) nanoparticles (NPs) were synthesized using the double-emission precipitation method and the obtained NPs were characterized with a Zeta Sizer, UV-Vis, Fourier transform infrared-attenuated total reflection spectrometers, scanning electron microscopy, and transmission electron microscopy. The in vitro release profile of the peptide-loaded PCL NPs was determined. In molecular modeling studies, PCL, PCL-polyvinyl alcohol (PVA), and PCL-PVA-YKT systems were simulated in an aqueous medium by molecular dynamics simulations, separately. The information about the interactions between the YKT tripeptide and the epidermal growth factor and androgen, estrogen, and progesterone receptors were obtained with the molecular docking study. Additionally, the ADME profile of YKT was determined as a result of each docking study. In conclusion, tripeptide-based nanodrug development studies of the YKT tripeptide are presented in this study.
dc.language.isoeng
dc.subjectSağlık Bilimleri
dc.subjectEczacılık
dc.subjectTemel Eczacılık Bilimleri
dc.subjectYaşam Bilimleri
dc.subjectBiyokimya
dc.subjectAlkoloidler
dc.subjectTemel Bilimler
dc.subjectPharmacology
dc.subjectGeneral Pharmacology, Toxicology and Pharmaceutics
dc.subjectPharmacology, Toxicology and Pharmaceutics (miscellaneous)
dc.subjectChemistry (miscellaneous)
dc.subjectGeneral Chemistry
dc.subjectPharmacology (medical)
dc.subjectPharmacy
dc.subjectFarmakoloji ve Toksikoloji
dc.subjectPhysical Sciences
dc.subjectLife Sciences
dc.subjectHealth Sciences
dc.subjectDrug Guides
dc.subjectYaşam Bilimleri (LIFE)
dc.subjectFARMAKOLOJİ VE ECZACILIK
dc.subjectKİMYA, MULTİDİSİPLİNER
dc.subjectTemel Bilimler (SCI)
dc.subjectKimya
dc.subjectKİMYA, TIP
dc.titleMolecular docking studies of YKT tripeptide and drug delivery system with poly(epsilon-caprolactone) nanoparticles
dc.typeMakale
dc.relation.journalARCHIV DER PHARMAZIE
dc.contributor.departmentİstanbul Üniversitesi , Fen Fakültesi , Fizik Bölümü
dc.contributor.firstauthorID3397248


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