Is There an Association Between Initial Clinical Manifestations and the Development of Macrophage Activation Syndrome in Patients with Systemic Juvenile Idiopathic Arthritis?

Abstract

Objective: Systemic juvenile idiopathic arthritis is deemed as a subtype of the disease complex known as juvenile idiopathic arthritis but differs in the point of its clinical manifestations and pathophysiological features. Besides, macrophage activation syndrome is a potentially fatal complication of systemic juvenile idiopathic arthritis requiring timely management. The study aims to evaluate the presence and recurrence of macrophage activation syndrome according to the initial symptoms and pattern of different phenotypes in systemic juvenile idiopathic arthritis to reveal the comprehensive association of these interrelated disorders.