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dc.contributor.authorArslan, Serdar
dc.contributor.authorEREN, İbrahim
dc.contributor.authorInanli, Ikbal
dc.contributor.authorCaliskan, Ali Metehan
dc.contributor.authorCicek, Ismet Esra
dc.contributor.authorTanrikulu, Ali Baran
dc.date.accessioned2022-07-04T12:28:39Z
dc.date.available2022-07-04T12:28:39Z
dc.identifier.citationTanrikulu A. B. , Inanli I., Arslan S., Caliskan A. M. , Cicek I. E. , EREN İ., "White matter characteristics in the early and late stages of bipolar disorder: A diffusion tensor imaging study", JOURNAL OF AFFECTIVE DISORDERS, cilt.308, ss.353-359, 2022
dc.identifier.issn0165-0327
dc.identifier.othervv_1032021
dc.identifier.otherav_1e533bff-1ad5-470a-b79e-8aa7d88f3d9a
dc.identifier.urihttp://hdl.handle.net/20.500.12627/181864
dc.identifier.urihttps://doi.org/10.1016/j.jad.2022.04.002
dc.description.abstractBackground: Bipolar disorder (BD) is characterized by recurrent mood episodes that may progress over time. Staging models may be used to follow the long-term course of BD. BD is associated with microstructural changes in white matter (WM). This study aims to compare the WM integrity within patients groups who are in different stages of BD and healthy controls and investigate whether WM integrity changes may be a biomarker that can be used in the clinical staging of BD. Methods: The study sample included euthymic 54 patients diagnosed with BD according to Diagnostic and Statistical Manual of Mental Disorders-IV (DSM-IV) and 27 healthy volunteers. Early-stage patients (n = 26) were determined as patients who have not had any mood episodes after the first manic episode, and late-stage patients (n = 28) determined as patients with recurrent mood episodes. MRI was performed using a 1.5 Tesla MR system and DTI sequences were acquired. Results: Region of interest (ROI) analyses showed that late-stage patients had significantly reduced fractional anisotropy (FA) in the right sagittal stratum and genu of the corpus callosum compared with healthy controls and early-stage patients. Regression models show that corpus callosum genu and right sagittal stratum FA values are predictive for the late-stage patient group. Limitations: There are some limitations of the ROI method. The cross-sectional design is another limitation of this study. Conclusions: WM integrity of corpus callosum genu and right sagittal stratum may be a biomarker for clinical staging of BD. Identifying stage-specific biomarkers may help us predict the neuroprogressive course of BD. Longitudinal studies would be required to detect stage-specific biomarkers.
dc.language.isoeng
dc.subjectNöroloji
dc.subjectNeurology
dc.subjectPsychiatric Mental Health
dc.subjectNeurology (clinical)
dc.subjectPsychiatry and Mental Health
dc.subjectLife Sciences
dc.subjectHealth Sciences
dc.subjectSağlık Bilimleri
dc.subjectDahili Tıp Bilimleri
dc.subjectTıp
dc.subjectPsikiyatri
dc.subjectKlinik Tıp (MED)
dc.subjectKlinik Tıp
dc.subjectKLİNİK NEUROLOJİ
dc.titleWhite matter characteristics in the early and late stages of bipolar disorder: A diffusion tensor imaging study
dc.typeMakale
dc.relation.journalJOURNAL OF AFFECTIVE DISORDERS
dc.contributor.departmentElazig Mental Hlth & Dis Hosp , ,
dc.identifier.volume308
dc.identifier.startpage353
dc.identifier.endpage359
dc.contributor.firstauthorID3431463


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