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dc.contributor.authorUrowitz, Murray
dc.contributor.authorGladman, Dafna D.
dc.contributor.authorHanly, John
dc.contributor.authorIsenberg, David
dc.contributor.authorJacobsen, Soren
dc.contributor.authorJames, Judith A.
dc.contributor.authorJonsen, Andreas
dc.contributor.authorKalunian, Kenneth
dc.contributor.authorKamen, Diane L.
dc.contributor.authorLim, Sung Sam
dc.contributor.authorMorand, Eric
dc.contributor.authorMosca, Marta
dc.contributor.authorPeschken, Christine
dc.contributor.authorPons-Estel, Bernardo A.
dc.contributor.authorRahman, Anisur
dc.contributor.authorRamsey-Goldman, Rosalind
dc.contributor.authorReynolds, John
dc.contributor.authorRomero-Diaz, Juanita
dc.contributor.authorRuiz-Irastorza, Guillermo
dc.contributor.authorSanchez-Guerrero, Jorge
dc.contributor.authorSvenungsson, Elisabet
dc.contributor.authorVinet, Evelyne
dc.contributor.authorvan Vollenhoven, Ronald F.
dc.contributor.authorVoskuyl, Alexandre
dc.contributor.authorWallace, Daniel J.
dc.contributor.authorPetri, Michelle A.
dc.contributor.authorManzi, Susan
dc.contributor.authorClarke, Ann Elaine
dc.contributor.authorCheung, Mike
dc.contributor.authorFarewell, Vernon
dc.contributor.authorAlarcon, Graciela S.
dc.contributor.authorUgarte-Gil, Manuel Francisco
dc.contributor.authorMak, Anselm
dc.contributor.authorLeong, Joanna
dc.contributor.authorDharmadhikari, Bhushan
dc.contributor.authorKow, Nien Yee
dc.contributor.authorReategui-Sokolova, Cristina
dc.contributor.authorElera-Fitzcarrald, Claudia
dc.contributor.authorAranow, Cinthia
dc.contributor.authorArnaud, Laurent
dc.contributor.authorAskanase, Anca D.
dc.contributor.authorİNANÇ, Murat
dc.contributor.authorBae, Sang-Cheol
dc.contributor.authorBernatsky, Sasha
dc.contributor.authorBruce, Ian N.
dc.contributor.authorBuyon, Jill
dc.contributor.authorCostedoat-Chalumeau, Nathalie
dc.contributor.authorDooley, Mary Ann
dc.contributor.authorFortin, Paul R.
dc.contributor.authorGinzler, Ellen M.
dc.date.accessioned2022-07-04T12:49:54Z
dc.date.available2022-07-04T12:49:54Z
dc.date.issued2021
dc.identifier.citationUgarte-Gil M. F. , Mak A., Leong J., Dharmadhikari B., Kow N. Y. , Reategui-Sokolova C., Elera-Fitzcarrald C., Aranow C., Arnaud L., Askanase A. D. , et al., "Impact of glucocorticoids on the incidence of lupus-related major organ damage: a systematic literature review and meta-regression analysis of longitudinal observational studies", LUPUS SCIENCE & MEDICINE, cilt.8, sa.1, 2021
dc.identifier.issn2053-8790
dc.identifier.othervv_1032021
dc.identifier.otherav_2dc8ecf3-da34-482e-a801-dc80d292bca7
dc.identifier.urihttp://hdl.handle.net/20.500.12627/182131
dc.identifier.urihttps://doi.org/10.1136/lupus-2021-000590
dc.description.abstractObjective In systemic lupus erythematosus (SLE), disease activity and glucocorticoid (GC) exposure are known to contribute to irreversible organ damage. We aimed to examine the association between GC exposure and organ damage occurrence. Methods We conducted a literature search (PubMed (Medline), Embase and Cochrane January 1966-October 2021). We identified original longitudinal observational studies reporting GC exposure as the proportion of users and/or GC use with dose information as well as the occurrence of new major organ damage as defined in the Systemic Lupus International Collaborating Clinics/American College of Rheumatology Damage Index. Meta-regression analyses were performed. Reviews, case-reports and studies with <5 years of follow-up, <50 patients, different outcomes and special populations were excluded. Results We selected 49 articles including 16 224 patients, 14 755 (90.9%) female with a mean age and disease duration of 35.1 years and of 37.1 months. The mean follow-up time was 104.9 months. For individual damage items, the average daily GC dose was associated with the occurrence of overall cardiovascular events and with osteoporosis with fractures. A higher average cumulative dose adjusted (or not)/number of follow-up years and a higher proportion of patients on GC were associated with the occurrence of osteonecrosis. Conclusions We confirm associations of GC use with three specific damage items. In treating patients with SLE, our aim should be to maximise the efficacy of GC and to minimise their harms.
dc.language.isoeng
dc.subjectKlinik Tıp (MED)
dc.subjectSağlık Bilimleri
dc.subjectDahili Tıp Bilimleri
dc.subjectİç Hastalıkları
dc.subjectİmmünoloji ve Romatoloji
dc.subjectRheumatology
dc.subjectKlinik Tıp
dc.subjectTıp
dc.subjectHealth Sciences
dc.subjectROMATOLOJİ
dc.titleImpact of glucocorticoids on the incidence of lupus-related major organ damage: a systematic literature review and meta-regression analysis of longitudinal observational studies
dc.typeMakale
dc.relation.journalLUPUS SCIENCE & MEDICINE
dc.contributor.departmentHosp Nacl Guillermo Almenara Irigoyen , ,
dc.identifier.volume8
dc.identifier.issue1
dc.contributor.firstauthorID3432540


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