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dc.contributor.authorJood, Katarina
dc.contributor.authorCai, Mengfei
dc.contributor.authorAarnio, Karoliina
dc.contributor.authorArauz, Antonio
dc.contributor.authorArnold, Marcel
dc.contributor.authorBae, Hee-Joon
dc.contributor.authorBandeo, Lucrecia
dc.contributor.authorBarboza, Miguel A.
dc.contributor.authorBolognese, Manuel
dc.contributor.authorBonardo, Pablo
dc.contributor.authorBrouns, Raf
dc.contributor.authorPacio, Gisele
dc.contributor.authorPatel, Vinod B.
dc.contributor.authorPhillips, Matthew C.
dc.contributor.authorPiechowski-Jozwiak, Bartlomiej
dc.contributor.authorPikula, Aleksandra
dc.contributor.authorRuiz-Sandoval, Jose
dc.contributor.authorvon Sarnowski, Bettina
dc.contributor.authorSwartz, Richard H.
dc.contributor.authorTan, Kay-Sin
dc.contributor.authorTanne, David
dc.contributor.authorTatlisumak, Turgut
dc.contributor.authorThijs, Vincent
dc.contributor.authorViana-Baptista, Miguel
dc.contributor.authorVibo, Riina
dc.contributor.authorWu, Teddy Y.
dc.contributor.authorYesilot, Nilufer
dc.contributor.authorWaje-Andreassen, Ulrike
dc.contributor.authorPezzini, Alessandro
dc.contributor.authorPutaala, Jukka
dc.contributor.authorTuladhar, Anil M.
dc.contributor.authorde Leeuw, Frank-Erik
dc.contributor.authorFromm, Annette
dc.contributor.authorGattringer, Thomas
dc.contributor.authorEkizoglu, Esme
dc.contributor.authorJacob, Mina A.
dc.contributor.authorEkker, Merel S.
dc.contributor.authorAllach, Youssra
dc.contributor.authorChuluun, Batnairamdal
dc.contributor.authorChuluunbatar, Enkhzaya
dc.contributor.authorCordonnier, Charlotte
dc.contributor.authorDagvajantsan, Byambasuren
dc.contributor.authorDebette, Stephanie
dc.contributor.authorDon, Adi
dc.contributor.authorEnzinger, Chris
dc.contributor.authorFandler-Hofler, Simon
dc.contributor.authorHora, Thiago F.
dc.contributor.authorJern, Christina
dc.contributor.authorFazekas, Franz
dc.contributor.authorKim, Young Seo
dc.contributor.authorKittner, Steven
dc.contributor.authorKleinig, Timothy
dc.contributor.authorKlijn, Catharina J. M.
dc.contributor.authorKorv, Janika
dc.contributor.authorKumar, Vinod
dc.contributor.authorLee, Keon-Joo
dc.contributor.authorLee, Tsong-Hai
dc.contributor.authorMaaijwee, Noortje A. M.
dc.contributor.authorMartinez-Majander, Nicolas
dc.contributor.authorMarto, Joao P.
dc.contributor.authorMehndiratta, Man M.
dc.contributor.authorMifsud, Victoria
dc.contributor.authorMontanaro, Vinicius
dc.date.accessioned2022-07-04T15:45:09Z
dc.date.available2022-07-04T15:45:09Z
dc.date.issued2022
dc.identifier.citationJacob M. A. , Ekker M. S. , Allach Y., Cai M., Aarnio K., Arauz A., Arnold M., Bae H., Bandeo L., Barboza M. A. , et al., "Global Differences in Risk Factors, Etiology, and Outcome of Ischemic Stroke in Young Adults-A Worldwide Meta-analysis The GOAL Initiative", NEUROLOGY, cilt.98, sa.6, 2022
dc.identifier.issn0028-3878
dc.identifier.othervv_1032021
dc.identifier.otherav_c09540cb-33cb-49a0-9436-12ebb327fb68
dc.identifier.urihttp://hdl.handle.net/20.500.12627/184522
dc.identifier.urihttps://doi.org/10.1212/wnl.0000000000013195
dc.description.abstractBackground and Objectives There is a worldwide increase in the incidence of stroke in young adults, with major regional and ethnic differences. Advancing knowledge of ethnic and regional variation in causes and outcomes will be beneficial in implementation of regional health care services. We studied the global distribution of risk factors, causes, and 3-month mortality of young patients with ischemic stroke, by performing a patient data meta-analysis from different cohorts worldwide. Methods We performed a pooled analysis of individual patient data from cohort studies that included consecutive patients with ischemic stroke aged 18-50 years. We studied differences in prevalence of risk factors and causes of ischemic stroke between different ethnic and racial groups, geographic regions, and countries with different income levels. We investigated differences in 3-month mortality by mixed-effects multivariable logistic regression. Results We included 17,663 patients from 32 cohorts in 29 countries. Hypertension and diabetes were most prevalent in Black (hypertension, 52.1%; diabetes, 20.7%) and Asian patients (hypertension 46.1%, diabetes, 20.9%). Large vessel atherosclerosis and small vessel disease were more often the cause of stroke in high-income countries (HICs; both p < 0.001), whereas "other determined stroke" and "undetermined stroke" were higher in low and middle-income countries (LMICs; both p < 0.001). Patients in LMICs were younger, had less vascular risk factors, and despite this, more often died within 3 months than those from HICs (odds ratio 2.49; 95% confidence interval 1.42-4.36). Discussion Ethnoracial and regional differences in risk factors and causes of stroke at young age provide an understanding of ethnic and racial and regional differences in incidence of ischemic stroke. Our results also highlight the dissimilarities in outcome after stroke in young adults that exist between LMICs and HICs, which should serve as call to action to improve health care facilities in LMICs.
dc.language.isoeng
dc.subjectKlinik Tıp
dc.subjectKLİNİK NEUROLOJİ
dc.subjectSağlık Bilimleri
dc.subjectDahili Tıp Bilimleri
dc.subjectNöroloji
dc.subjectNeurology
dc.subjectNeurology (clinical)
dc.subjectLife Sciences
dc.subjectHealth Sciences
dc.subjectKlinik Tıp (MED)
dc.subjectTıp
dc.titleGlobal Differences in Risk Factors, Etiology, and Outcome of Ischemic Stroke in Young Adults-A Worldwide Meta-analysis The GOAL Initiative
dc.typeMakale
dc.relation.journalNEUROLOGY
dc.contributor.departmentUniversity of Bergen , ,
dc.identifier.volume98
dc.identifier.issue6
dc.contributor.firstauthorID3391803


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