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dc.contributor.authorOyardi, Ozlem
dc.contributor.authorBozkurt-Guzel, Cagla
dc.contributor.authorSavage, Paul B.
dc.contributor.authorAltay, Havva Ozlem
dc.contributor.authorDemir, Elif Sena
dc.date.accessioned2022-07-04T15:52:14Z
dc.date.available2022-07-04T15:52:14Z
dc.identifier.citationDemir E. S. , Oyardi O., Savage P. B. , Altay H. O. , Bozkurt-Guzel C., "In vitro activity of ceragenins against Burkholderia cepacia complex", JOURNAL OF ANTIBIOTICS, 2022
dc.identifier.issn0021-8820
dc.identifier.othervv_1032021
dc.identifier.otherav_c738068c-cf7b-48a0-87f9-2e545d257ad1
dc.identifier.urihttp://hdl.handle.net/20.500.12627/184632
dc.identifier.urihttps://doi.org/10.1038/s41429-022-00530-w
dc.description.abstractBurkholderia cepacia complex (Bcc) species are aerobic, Gram-negative and non-fermantative bacilli. Bcc can cause clinical symptoms in patients with cystic fibrosis, ranging from asymptomatic carriage to fatal pneumonia. A pressing need exists for new antimicrobial agents that target Bcc. Ceragenins, CSA-13, CSA-131 and CSA-131 with 5% Pluronic (R) F127 (CSA-131P), were evaluated against Bcc clinical isolates (n = 42). MICs of ceragenins and conventional antibiotics were determined. Time-kill curve experiments were performed with 1x, 4x MICs of ceragenins and sulfamethoxazole-trimethoprim (SXT), levofloxacin. MIC50/ MIC90 results (mg l(-1)) of CSA-13, CSA-131 and CSA-131P were determined as 16/64, 16/128 and 16/128, respectively. CSA-13 and CSA-131 showed bactericidal activity. CSA-13 - levofloxacin combination displayed synergistic activity against Bcc. First-generation (CSA-13) and second-generation (CSA-131 and CSA-131P) ceragenins have significant antimicrobial effects on Bcc. The findings of this study demonstrate that combinations of ceragenins with currently marketed antibiotics could be synergistic in vitro against Bcc isolates. These results suggest that combination therapy with conventional antibiotics could be an alternative approach for treating Bcc infections in the future.
dc.language.isoeng
dc.subjectEczacılık
dc.subjectTemel Eczacılık Bilimleri
dc.subjectYaşam Bilimleri
dc.subjectBiyoteknoloji
dc.subjectTemel Bilimler
dc.subjectGeneral Immunology and Microbiology
dc.subjectPharmacology
dc.subjectImmunology
dc.subjectBiotechnology
dc.subjectGeneral Pharmacology, Toxicology and Pharmaceutics
dc.subjectApplied Microbiology and Biotechnology
dc.subjectPharmacology, Toxicology and Pharmaceutics (miscellaneous)
dc.subjectMolecular Medicine
dc.subjectPharmacology (medical)
dc.subjectFarmakoloji ve Toksikoloji
dc.subjectDrug Guides
dc.subjectLife Sciences
dc.subjectHealth Sciences
dc.subjectPharmacy
dc.subjectSağlık Bilimleri
dc.subjectFARMAKOLOJİ VE ECZACILIK
dc.subjectİmmünoloji
dc.subjectYaşam Bilimleri (LIFE)
dc.subjectMikrobiyoloji
dc.subjectBİYOTEKNOLOJİ VE UYGULAMALI MİKROBİYOLOJİ
dc.titleIn vitro activity of ceragenins against Burkholderia cepacia complex
dc.typeMakale
dc.relation.journalJOURNAL OF ANTIBIOTICS
dc.contributor.departmentİstanbul Teknik Üniversitesi , ,
dc.contributor.firstauthorID3423690


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