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dc.contributor.authorBAHAR TOKMAN, HRİSİ
dc.contributor.authorDemirci, Mehmet
dc.contributor.authorTaner, Zeynep
dc.contributor.authorKeskin, Fatma E.
dc.contributor.authorOzyazar, Mucahit
dc.contributor.authorKiraz, Nuri
dc.contributor.authorKOCAZEYBEK, BEKİR SAMİ
dc.date.accessioned2023-02-21T07:25:58Z
dc.date.available2023-02-21T07:25:58Z
dc.date.issued2022
dc.identifier.citationDemirci M., Taner Z., Keskin F. E., Ozyazar M., Kiraz N., KOCAZEYBEK B. S., BAHAR TOKMAN H., "Similar bacterial signatures in the gut microbiota of type 1 and type 2 diabetes patients and its association with G protein-coupled receptor 41 and 43 gene expression", JOURNAL OF DIABETES AND METABOLIC DISORDERS, cilt.21, sa.2, ss.1359-1368, 2022
dc.identifier.issn2251-6581
dc.identifier.otherav_065144fc-4f22-4486-aa5b-3caf36815401
dc.identifier.othervv_1032021
dc.identifier.urihttp://hdl.handle.net/20.500.12627/185800
dc.identifier.urihttps://doi.org/10.1007/s40200-022-01068-2
dc.description.abstractPurpose There are conflicting reports regarding the abundance of short-chain fatty acids producing bacteria in the gut microbiota in patients with type 1 and type 2 diabetes. We aimed to determine the amount of Akkermansia muciniphila, Anaerobutyricum hallii, Bifidobacterium adolescentis, Bifidobacterium longum, Collinsella aerofaciens, Faecalibacterium prausnitzii, Lacticaseibacillus rhamnosus, and Parabacteroides distasonis in the gut microbiota in patients with type1 and type2 diabetes, compared with the healthy controls and analyze the correlation between the gene expression levels of two short-chain fatty acids receptors GPR41 and GPR43. Methods Forty type 1, 40 type 2 stool and blood samples of diabetes patients, and 40 healthy control samples were studied. DNA and RNA were extracted, and bacteria were detected using a Microbial DNA qPCR Assay kit. Gene expressions were detected with GPR41 and GPR43 primers via in-house qPCR. Results Compared with healthy controls, B.longum and F.prausnitzii abundance were significantly decreased in patients with type1 and type2 diabetes, A.hallii abundance was increased in patients with type1 and decreased in type2 diabetes contrarily A.muciniphila abundance was decreased in patients with type1 and increased in type2 diabetes. GPR43 gene expression was upregulated in both patients group, however GPR41 was upregulated only in patients with type2 diabetes. Conclusions Elevated B. longum and F. prausnitzii abundances were detected in the gut microbiota of patients with type1 and type2 diabetes and compared with healthy controls. B. longum and F.prausnitzii abundances were also correlated with the GPR43 gene expression level in type1 diabetes patients. Extensive studies determining bacteria producing short-chain fatty acids in gut microbiota, and their contribution in the pathogenesis of diabetes, are needed to understand better the mechanism of these diseases.
dc.language.isoeng
dc.subjectİç Hastalıkları
dc.subjectENDOKRİNOLOJİ VE METABOLİZMA
dc.subjectKlinik Tıp
dc.subjectKlinik Tıp (MED)
dc.subjectTıp
dc.subjectSağlık Bilimleri
dc.subjectDahili Tıp Bilimleri
dc.subjectEndokrinoloji ve Metabolizma Hastalıkları
dc.subjectEndocrinology
dc.subjectEndocrine and Autonomic Systems
dc.subjectEndocrinology, Diabetes and Metabolism
dc.subjectLife Sciences
dc.subjectHealth Sciences
dc.titleSimilar bacterial signatures in the gut microbiota of type 1 and type 2 diabetes patients and its association with G protein-coupled receptor 41 and 43 gene expression
dc.typeMakale
dc.relation.journalJOURNAL OF DIABETES AND METABOLIC DISORDERS
dc.contributor.departmentKırklareli Üniversitesi , ,
dc.identifier.volume21
dc.identifier.issue2
dc.identifier.startpage1359
dc.identifier.endpage1368
dc.contributor.firstauthorID3435048


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