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dc.contributor.authorUncu, Gokce Sultan
dc.contributor.authorSoylu, Nusret
dc.contributor.authorKarayagmurlu, Ali
dc.contributor.authorKaynar, Tuba Bilbay
dc.contributor.authorVural, Pervin
dc.contributor.authorBaki, Adile Merve
dc.date.accessioned2023-02-21T07:28:56Z
dc.date.available2023-02-21T07:28:56Z
dc.date.issued2022
dc.identifier.citationUncu G. S., Karayagmurlu A., Kaynar T. B., Baki A. M., Vural P., Soylu N., "Serum Levels of Brain-Derived Neurotrophic Factor, Nerve Growth Factor, Neurotrophin-3, and Glial-Derived Neurotrophic Factor in Children with Specific Learning Disorder", NOROPSIKIYATRI ARSIVI-ARCHIVES OF NEUROPSYCHIATRY, cilt.59, sa.4, ss.260-267, 2022
dc.identifier.issn1300-0667
dc.identifier.otherav_0706a51d-38f4-4866-96e5-8bd61752216a
dc.identifier.othervv_1032021
dc.identifier.urihttp://hdl.handle.net/20.500.12627/185840
dc.identifier.urihttps://doi.org/10.29399/npa.28043
dc.description.abstractIntroduction: Specific learning disorder (SLD) is a neurodevelopmental disorder that involves complex interactions of genetic, neurobiological and environmental factors, but the definite mechanisms remain mostly unknown. The possible role of neurotrophins has been implicated in the pathophysiology of various neurodevelopmental disorders. This study aimed to investigate whether serum levels of brain-derived neurotrophic factor (BDNF), glial-derived neurotrophic factor (GDNF), nerve growth factor (NGF), and neurotrophin-3 (NT-3) in children with SLD deviate from those of neurotypical brains.Methods: Forty-four patients with SLD and 44 healthy controls aged 7 - 12 years were included. SLD diagnosis and severity was determined using DSM-5-based interviews and SLD clinical observation battery. Serum neurotrophins were measured using enzyme-linked immunosorbent assay.Results: BDNF (p=0.032), NGF (p=0.029), and NT-3 (p=0.025) serum levels were significantly higher in the SLD group compared to the control group; however, serum levels of GDNF did not show any significant difference between groups. On the other hand, GDNF serum levels were significantly different between mild and severe SLD groups (p=0.007) and were lower in severe SLD subjects than in mild cases. There was also a significant correlation between patients' reading speeds and serum levels of GDNF (p=0.025), and GDNF serum levels were lower in patients with slower reading speeds.Conclusion: These findings suggest that neurotrophins might play a role in the pathophysiology of SLD. Increased serum levels of BDNF, NGF, and NT-3 might reflect compensatory attempts at neuroprotection against neurodevelopmental impairment.
dc.language.isoeng
dc.subjectYaşam Bilimleri
dc.subjectDahili Tıp Bilimleri
dc.subjectNöroloji (klinik)
dc.subjectNöroloji
dc.subjectSağlık Bilimleri
dc.subjectTıp
dc.subjectKlinik Tıp (MED)
dc.subjectKlinik Tıp
dc.subjectKLİNİK NÖROLOJİ
dc.titleSerum Levels of Brain-Derived Neurotrophic Factor, Nerve Growth Factor, Neurotrophin-3, and Glial-Derived Neurotrophic Factor in Children with Specific Learning Disorder
dc.typeMakale
dc.relation.journalNOROPSIKIYATRI ARSIVI-ARCHIVES OF NEUROPSYCHIATRY
dc.contributor.departmentİstanbul Üniversitesi , İstanbul Tıp Fakültesi , Temel Tıp Bilimleri Bölümü
dc.identifier.volume59
dc.identifier.issue4
dc.identifier.startpage260
dc.identifier.endpage267
dc.contributor.firstauthorID4156473


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