Show simple item record

dc.contributor.authorKeskin, Seda Eren
dc.contributor.authorTsatsakis, Aristides M.
dc.contributor.authorSevim, Cigdem
dc.contributor.authorVeskoukis, Aristidis S.
dc.contributor.authorKuzmin, Sergei
dc.contributor.authorKARA, Mehtap
dc.contributor.authorÖZTAŞ, Ezgi
dc.contributor.authorBoran, Tugce
dc.date.accessioned2023-02-21T07:30:32Z
dc.date.available2023-02-21T07:30:32Z
dc.identifier.citationKARA M., ÖZTAŞ E., Boran T., Sevim C., Keskin S. E., Veskoukis A. S., Kuzmin S., Tsatsakis A. M., "The sesquiterpenoid valerenic acid protects neuronal cells from the detrimental effects of the fungicide benomyl on apoptosis and DNA oxidation", HUMAN & EXPERIMENTAL TOXICOLOGY, cilt.41, 2022
dc.identifier.issn0960-3271
dc.identifier.othervv_1032021
dc.identifier.otherav_075f2a58-d32f-4154-bae5-3ac486a38aca
dc.identifier.urihttp://hdl.handle.net/20.500.12627/185859
dc.identifier.urihttps://doi.org/10.1177/09603271221101038
dc.description.abstractBackground Valerenic acid (VA), a sesquiterpenoid of the plant Valeriana officinalis, has attracted attention of the research community due to its potential positive role against neurodegenerative diseases induced by chemicals. However, the relevant evidence in the literature is scarce. Therefore, this study aimed to examine the putative protective role of VA on the toxic effects of the fungicide benomyl on SH-SY5Y neural cells. Methods Cell viability was determined via the MTT and NRU assays, DNA damage was assessed via comet assay and apoptosis was evaluated through the expression of relevant genes. Results According to the results, exposure of the cells to benomyl enhanced viability inhibition and promoted DNA damage and apoptosis since the expression levels of the genes coding for MAPK8, NF-kB, Bax, Caspase-9 and Caspase-3 were increased. Treatment of the cells with VA ameliorated these effects in a concentration dependent manner. Conclusion It is concluded that the molecular mechanism through which benomyl exerts its toxic action appears to depend on DNA oxidation and apoptosis induction. Furthermore, VA, a plant-derived compound is a protective antioxidant against pesticide-induced toxicity. Therefore, herbs, extracts and compounds of plant origin could be used as nutritional supplements that back up the beneficial role of medicine in neurodegenerative diseases.
dc.language.isoeng
dc.subjectYaşam Bilimleri
dc.subjectTemel Bilimler
dc.subjectToksikoloji
dc.subjectFarmakoloji, Toksikoloji ve Eczacılık (çeşitli)
dc.subjectSağlık, Toksikoloji ve Mutajenez
dc.subjectFizik Bilimleri
dc.subjectMeslek Bilimleri
dc.subjectFarmasötik Toksikoloji
dc.subjectEczacılık
dc.subjectSağlık Bilimleri
dc.subjectYaşam Bilimleri (LIFE)
dc.subjectFarmakoloji ve Toksikoloji
dc.subjectTOKSİKOLOJİ
dc.titleThe sesquiterpenoid valerenic acid protects neuronal cells from the detrimental effects of the fungicide benomyl on apoptosis and DNA oxidation
dc.typeMakale
dc.relation.journalHUMAN & EXPERIMENTAL TOXICOLOGY
dc.contributor.departmentİstanbul Üniversitesi , Eczacılık Fakültesi , Eczacılık Meslek Bilimleri Bölümü
dc.identifier.volume41
dc.contributor.firstauthorID3440255


Files in this item

FilesSizeFormatView

There are no files associated with this item.

This item appears in the following Collection(s)

Show simple item record