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dc.contributor.authorIzgi, B.
dc.contributor.authorIstemihan, Zülal
dc.contributor.authorKaymakoglu, S.
dc.contributor.authorDemir, K.
dc.contributor.authorOrmeci, Aslı
dc.contributor.authorBayraktar, S.
dc.contributor.authorIsik, A. O.
dc.contributor.authorCavus, B.
dc.contributor.authorAkas, R.
dc.contributor.authorSaridal, M. K.
dc.contributor.authorAkyuz, F.
dc.contributor.authorBesisik, F.
dc.date.accessioned2023-02-21T07:33:15Z
dc.date.available2023-02-21T07:33:15Z
dc.date.issued2022
dc.identifier.citationOrmeci A., Bayraktar S., Isik A. O., Cavus B., Akas R., Istemihan Z., Saridal M. K., Akyuz F., Besisik F., Kaymakoglu S., et al., "Is anterior segment OCT superior to slit-lamp biomicroscopic examination for Kayser Flesicher ring in Wilson's disease?", European review for medical and pharmacological sciences, cilt.26, sa.14, ss.5178-5185, 2022
dc.identifier.issn1128-3602
dc.identifier.othervv_1032021
dc.identifier.otherav_08732a9b-6fef-441d-becd-a5415a9a4c16
dc.identifier.urihttp://hdl.handle.net/20.500.12627/185904
dc.identifier.urihttps://doi.org/10.26355/eurrev_202207_29306
dc.identifier.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85135392357&origin=inward
dc.description.abstract© 2022 Verduci Editore s.r.l. All rights reserved.OBJECTIVE: Detection of the Kayser-Fleischer (KF) ring in the diagnostic scoring and treatment follow-up of Wilson’s Disease (WD) is important. Slit lamp (SL) biomicroscopic examination has traditionally been used in the evaluation of the KF ring. The role of Anterior Segment Optical Coherence Tomography (AS-OCT), which is used in various corneal diseases, in the detection of KF rings has attracted attention in recent years. In our study, we tried to demonstrate the effectiveness of AS-OCT in detecting the KF ring by comparing it with SL biomicroscopic examination. PATIENTS AND METHODS: 64 of 356 patients followed in our outpatient clinic due to WD were included in the study in the order of their admission to the outpatient clinic. The KF ring was evaluated in both eyes by SL-biomicroscopic examination and AS-OCT. Ophthalmic examination, and findings were performed by the same physician. RESULTS: Age range was 18-67 years, mean 33.06±10.83 years, gender was 39.1% (n: 25) female. At the time of diagnosis, the mean age was 19.48 ± 9.36 years, range was minimum 5 years and maximum 51 years. Clinical presentation was mixed type involvement n: 18 (28.1%), hepatic involvement n: 32 (50%), neurological involvement n: 14 (21.9%). The follow-up period was 2-257 months (74.6±76.16). The presence of KF ring was evaluated together with both AS-OCT and slit-lamp examination, the presence of KF could be detected in both AS-OCT and SL biomicroscopic examination in 10 patients (15.6%), in 12 (18.8%) of the cases KF ring is positive in AS-OCT but was negative in Slit-lamp biomicroscopic examination, in 65.6 (n: 42) of the cases OCT and slit-lamp biomicroscopic examination results were negative. CONCLUSIONS: The sensitivity of AS-OCT in detecting the KF ring was higher than the slit-lamp biomicroscopic examination. AS-OCT can detect early stage of KF rings in Wilson’s Disease patients, so that diagnosis and treatment accuracy can be evaluated effectively.
dc.language.isoeng
dc.subjectFarmakoloji, Toksikoloji ve Eczacılık (çeşitli)
dc.subjectGenel Farmakoloji, Toksikoloji ve Eczacılık
dc.subjectFarmakoloji (tıbbi)
dc.subjectİlaç Rehberleri
dc.subjectSağlık Bilimleri
dc.subjectTemel Bilimler
dc.subjectFarmakoloji
dc.subjectYaşam Bilimleri
dc.subjectTemel Eczacılık Bilimleri
dc.subjectEczacılık
dc.subjectYaşam Bilimleri (LIFE)
dc.subjectFarmakoloji ve Toksikoloji
dc.subjectFARMAKOLOJİ VE ECZACILIK
dc.titleIs anterior segment OCT superior to slit-lamp biomicroscopic examination for Kayser Flesicher ring in Wilson's disease?
dc.typeMakale
dc.relation.journalEuropean review for medical and pharmacological sciences
dc.contributor.departmentİstanbul Üniversitesi , İstanbul Tıp Fakültesi , Cerrahi Tıp Bilimleri Bölümü
dc.identifier.volume26
dc.identifier.issue14
dc.identifier.startpage5178
dc.identifier.endpage5185
dc.contributor.firstauthorID4059034


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