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dc.contributor.authorERCAN, ALEV MELTEM
dc.contributor.authorKaris, Denizhan
dc.contributor.authorAlkan, Fatma Ates
dc.contributor.authorÇETİN, GÜVEN
dc.contributor.authorTekin, Tuba Ozkan
dc.date.accessioned2023-02-21T07:38:58Z
dc.date.available2023-02-21T07:38:58Z
dc.identifier.citationTekin T. O., Karis D., Alkan F. A., ÇETİN G., ERCAN A. M., "Evaluation of trace elements in essential thrombocytosis and reactive thrombocytosis", JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY, cilt.73, 2022
dc.identifier.issn0946-672X
dc.identifier.othervv_1032021
dc.identifier.otherav_0a62b82a-232d-4c67-a454-1684f3366ef3
dc.identifier.urihttp://hdl.handle.net/20.500.12627/185981
dc.identifier.urihttps://doi.org/10.1016/j.jtemb.2022.127034
dc.description.abstractBackground: Trace elements (TE) are vital for cellular mechanisms at biological, chemical and molecular levels. The effects of TE in diagnosis, progression and treatment of essential thrombocytosis (ET), which is one of the chronic myeloproliferative neoplasms is a rare clonal stem cell disease characterized by increased thrombocyte numbers with impaired function, have not been elucidated in detail yet. The aim of the present study was to investigate the effects of TE alterations in an ET model and the efficacy of TE in ET treatment protocol by means of a vast number of TE.Methods: Study groups were categorized as patients with ET diagnosis (ET group, n:30), patients with reactive thrombocytosis secondary to iron deficiency anemia (IDA-RT) (IDA-RT group, n:30) and healthy controls (HC group, n:30). Serum levels of copper (Cu), iron (Fe), cobalt (Co), chromium (Cr), aluminum (Al), silicon (Si), nickel (Ni), zinc (Zn), selenium (Se), manganese (Mn), boron (B) and magnesium (Mg) were analyzed utilizing inductively coupled plasma-optical emission spectrophotometer instrument (ICP-OES). Statistical analysis was evaluated using SPSS 23.0.Results: ET group had statistically higher serum levels of Co and Mg (p < 0.05), Ni and Mn (p < 0.001), and lower Si (p < 0.05) than IDA-RT group. ET group had statistically higher serum levels of Co and Mn (p < 0.05), and Ni (p < 0.001), and lower Al, Si and Se (p < 0.001) than HC group. Serum levels of Fe, Al and Se (p < 0.001), and Mg (p < 0.01), and Zn (p < 0.05) in IDA-RT group were significantly lower than HC group.Conclusion: This novel study pointed out that alterations of many serum TE by means of both increment or decrement might have close relationship with mechanisms and complications of ET onset and follow-up. We consider that further research of TE would elucidate ethiopathogenesis and prognosis of ET. Thus, analysis of serum trace elements in essential thrombocytosis patients may be an important protocol by means of diagnosis, treatment and follow-up intervals.
dc.language.isoeng
dc.subjectEndokrinoloji
dc.subjectYaşam Bilimleri
dc.subjectMoleküler Biyoloji ve Genetik
dc.subjectSitogenetik
dc.subjectTemel Bilimler
dc.subjectİlaç Keşfi
dc.subjectEndokrin ve Otonom Sistemler
dc.subjectEndokrinoloji, Diyabet ve Metabolizma
dc.subjectYapısal Biyoloji
dc.subjectMoleküler Biyoloji
dc.subjectEndokrinoloji ve Metabolizma Hastalıkları
dc.subjectKlinik Biyokimya
dc.subjectKanser Araştırmaları
dc.subjectBiyokimya
dc.subjectYaşlanma
dc.subjectBiyokimya, Genetik ve Moleküler Biyoloji (çeşitli)
dc.subjectGenel Biyokimya, Genetik ve Moleküler Biyoloji
dc.subjectBİYOKİMYA VE MOLEKÜLER BİYOLOJİ
dc.subjectMoleküler Biyoloji ve Genetik
dc.subjectYaşam Bilimleri (LIFE)
dc.subjectENDOKRİNOLOJİ VE METABOLİZMA
dc.subjectKlinik Tıp
dc.subjectKlinik Tıp (MED)
dc.subjectTıp
dc.subjectSağlık Bilimleri
dc.subjectDahili Tıp Bilimleri
dc.subjectİç Hastalıkları
dc.titleEvaluation of trace elements in essential thrombocytosis and reactive thrombocytosis
dc.typeMakale
dc.relation.journalJOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY
dc.contributor.departmentBezmiâlem Vakıf Üniversitesi , ,
dc.identifier.volume73
dc.contributor.firstauthorID3441279


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