Show simple item record

dc.contributor.authorDEMİRCİOĞLU, SERAP
dc.contributor.authorGÜRAN, TÜLAY
dc.contributor.authorBORAN, PERRAN
dc.contributor.authorHAKLAR, GONCAGÜL
dc.contributor.authorBEREKET, ABDULLAH
dc.contributor.authorEnver, Ece Oge
dc.contributor.authorVatansever, Pinar
dc.contributor.authorGuran, Omer
dc.contributor.authorBİLGİN, Leyla
dc.date.accessioned2023-02-21T08:18:02Z
dc.date.available2023-02-21T08:18:02Z
dc.date.issued2022
dc.identifier.citationEnver E. O., Vatansever P., Guran O., BİLGİN L., BORAN P., DEMİRCİOĞLU S., HAKLAR G., BEREKET A., GÜRAN T., "Adrenal steroids reference ranges in infancy determined by LC-MS/MS", Pediatric Research, cilt.92, sa.1, ss.265-274, 2022
dc.identifier.issn0031-3998
dc.identifier.othervv_1032021
dc.identifier.otherav_17da527c-5a94-4c64-9902-3cd9e3102570
dc.identifier.urihttp://hdl.handle.net/20.500.12627/186530
dc.identifier.urihttps://doi.org/10.1038/s41390-021-01739-5
dc.identifier.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85115398432&origin=inward
dc.description.abstract© 2021, The Author(s), under exclusive licence to the International Pediatric Research Foundation, Inc.Background: Interpretation of the results of steroid hormone measurements is challenging at early infancy. The liquid chromatography-tandem mass spectrometry (LC-MS/MS) method provides a powerful tool for diagnosing steroidogenesis disorders. We aimed to develop normative data for a 14-steroid panel and four adrenal enzyme activity indices, determined by LC-MS/MS from 3 days to 6 months of age. Methods: Age- and sex-specific plasma steroid concentrations were calculated in 324 healthy full-term neonates and infants (151 females). Percentile curves were devised. Steroid ratios were evaluated as biomarkers of adrenal enzyme activities. The steroid profiles of four patients with adrenal enzyme deficiencies were included to test the diagnostic efficiency. Results: Nine steroids showed age, but none showed sex specificity. The concentrations of progestins and androgens were higher at 7–14 days than at 3–7 days. After the first month, adrenal androgen concentrations decreased significantly. Adrenal enzyme activities changed towards increasing cortisol over the first 6 months. There were several-fold differences in diagnostic steroids and related adrenal enzyme activity indices between the patients and the healthy group. Conclusions: The majority of adrenal steroids show age-related variations in the neonatal period and early infancy. Our data will enable accurate interpretation of steroid measurements for etiologic diagnosis of disorders of steroidogenesis. Impact: LC-MS/MS method is capable of quantitating numerous analytes simultaneously, which provides an integrated picture of adrenal steroidogenesis in a small amount of sample.The development of LC-MS/MS-based normative data of steroid hormones in healthy infants is crucial to differentiate physiologic alterations from steroidogenic defects during the first 3–6 months of infancy.Previous studies had limitations due to the small numbers of samples available by sex and by age groups.Our detailed normative data and percentile curves will enable accurate interpretation of steroid measurements for etiologic diagnosis of disorders of steroidogenesis without the need for further invasive testing.
dc.language.isoeng
dc.subjectSağlık Bilimleri
dc.subjectPediatri, Perinatoloji ve Çocuk Sağlığı
dc.subjectDahili Tıp Bilimleri
dc.subjectÇocuk Sağlığı ve Hastalıkları
dc.subjectTıp
dc.subjectPEDİATRİ
dc.subjectKlinik Tıp
dc.subjectKlinik Tıp (MED)
dc.titleAdrenal steroids reference ranges in infancy determined by LC-MS/MS
dc.typeMakale
dc.relation.journalPediatric Research
dc.contributor.departmentMarmara Üniversitesi , ,
dc.identifier.volume92
dc.identifier.issue1
dc.identifier.startpage265
dc.identifier.endpage274
dc.contributor.firstauthorID4144495


Files in this item

FilesSizeFormatView

There are no files associated with this item.

This item appears in the following Collection(s)

Show simple item record