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dc.contributor.authorPaerhati, Erxiati
dc.contributor.authorDogan, Ozlem
dc.contributor.authorErgonul, Onder
dc.contributor.authorCekic, Sebile Guler
dc.contributor.authorGursoy, Attila
dc.contributor.authorKeskin, Ozlem
dc.contributor.authorCan, Fusun
dc.contributor.authorCelik, Ebru
dc.contributor.authorOzcan, Gulin
dc.contributor.authorVatansever, Cansel
dc.contributor.authorKuskucu, Mert A.
dc.date.accessioned2023-02-21T08:19:45Z
dc.date.available2023-02-21T08:19:45Z
dc.date.issued2023
dc.identifier.citationCelik E., Ozcan G., Vatansever C., Paerhati E., Kuskucu M. A., Dogan O., Cekic S. G., Ergonul O., Gursoy A., Keskin O., et al., "Alterations in vaginal microbiota among pregnant women with COVID-19", JOURNAL OF MEDICAL VIROLOGY, cilt.95, sa.1, 2023
dc.identifier.issn0146-6615
dc.identifier.othervv_1032021
dc.identifier.otherav_187ca531-c261-4ccb-af54-b9c56e17eaaf
dc.identifier.urihttp://hdl.handle.net/20.500.12627/186557
dc.identifier.urihttps://doi.org/10.1002/jmv.28132
dc.description.abstractThe maintenance of vaginal microbiota is an important factor to achieve optimum pregnancy outcomes. The study aims to describe the alterations in the composition of vaginal microbiota in pregnant women with coronavirus disease 2019 (COVID-19). This was a prospective case-control study. Vaginal swabs were collected from uninfected pregnant women (n = 28) and pregnant women with COVID-19 (n = 19) during the active phase of infection and within a month after recovering from infection. The vaginal microbiota on the swabs was examined by 16S rRNA gene sequencing. Shannon index indicates that alpha diversity is significantly higher in women with COVID-19 (p = 0.012). There was a significant decrease in Firmicutes (p = 0.014) with an increase in Bacteroidota (p = 0.018) phyla and a decrease in Lactobacillus (p = 0.007) genus in women with COVID-19 than those of uninfected pregnant women. The relative abundance of L. crispatus, L. iners, L. gasseri, and L. jensenii were lower in the COVID-19 group than in uninfected pregnant women. In subgroup analysis, the amount of Ureaplasma spp. was higher in women with moderate/severe than those of asymptomatic/mild disease (p = 0.036). The study revealed that vaginal dysbiosis with low abundance of Lactobacillus species occurred in pregnant women infected with severe acute respiratory syndrome coronavirus-2. These findings may lead to new studies to elucidate the risk of pregnancy adverse outcomes related to COVID-19.
dc.language.isoeng
dc.subjectGenel İmmünoloji ve Mikrobiyoloji
dc.subjectVİROLOJİ
dc.subjectİmmünoloji
dc.subjectYaşam Bilimleri (LIFE)
dc.subjectTıp
dc.subjectMikrobiyoloji ve Klinik Mikrobiyoloji
dc.subjectViroloji
dc.subjectYaşam Bilimleri
dc.subjectSağlık Bilimleri
dc.subjectTemel Tıp Bilimleri
dc.subjectTemel Bilimler
dc.titleAlterations in vaginal microbiota among pregnant women with COVID-19
dc.typeMakale
dc.relation.journalJOURNAL OF MEDICAL VIROLOGY
dc.contributor.departmentAfyon Kocatepe Üniversitesi , ,
dc.identifier.volume95
dc.identifier.issue1
dc.contributor.firstauthorID3456716


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