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dc.contributor.authorYILDIZ, ÇAĞLAR
dc.contributor.authorYAYLIM, İlhan
dc.contributor.authorHepokur, Ceylan
dc.contributor.authorMISIR, SEMA
dc.contributor.authorOksasoglu, Bugra
dc.contributor.authorCaner, Armagan
dc.date.accessioned2023-02-21T08:29:42Z
dc.date.available2023-02-21T08:29:42Z
dc.date.issued2022
dc.identifier.citationYILDIZ Ç., Caner A., Oksasoglu B., MISIR S., YAYLIM İ., Hepokur C., "The role of cytokeratin 19 levels in the determination of endometriosis stages", GYNECOLOGICAL ENDOCRINOLOGY, cilt.38, sa.10, ss.879-884, 2022
dc.identifier.issn0951-3590
dc.identifier.othervv_1032021
dc.identifier.otherav_1bb33669-674b-46f6-851b-ed7481fc1df1
dc.identifier.urihttp://hdl.handle.net/20.500.12627/186712
dc.identifier.urihttps://doi.org/10.1080/09513590.2022.2120606
dc.description.abstractObjective/Aim Endometrisosis, one of the most common gynecological disease, is characterized by the presence of endometriotic tissue outside of uterine cavity. The development and the validation of a simple blood biomarker specific and sensitive for endometriosis may facilitate the rapid and the accurate diagnosis of the disease and thus early treatment. Cytokeratin expression changes during epithelial differentiation and this expression is important for the modulation and the control of cell cycle regulation, tumor cell motility and apoptosis. Cytokeratin 19 (CK-19) is expressed in most simple epithelial cells and their malignant counterparts. The aim of this study is to investigate serum CK-19 expression levels in patients with endometriosis and to determine the diagnostic role of CK-19 levels in differentiating various stage of endometriosis. Methods Ctytokeratin-19 expression and level were studied in 70 endometriosis patients and 50 volunteers by ELISA and RT-PCR. ROC analysis was performed by comparing all stages with each other and with the control group. Results The CK-19 levels were significantly higher in the endometriosis groups than that of the control group by ELISA and RT-PCR. A significant (p < .05) difference was observed in endometriosis patients according to the stages. Conclusion Based on our data, it suggests that Cytokeratin-19 may have a potential role in the development of endometriosis.
dc.language.isoeng
dc.subjectEndokrinoloji, Diyabet ve Metabolizma
dc.subjectDoğum ve Jinekoloji
dc.subjectEndokrin ve Otonom Sistemler
dc.subjectSağlık Bilimleri
dc.subjectKadın Hastalıkları ve Doğum
dc.subjectCerrahi Tıp Bilimleri
dc.subjectENDOKRİNOLOJİ VE METABOLİZMA
dc.subjectKlinik Tıp (MED)
dc.subjectKADIN HASTALIKLARI & DOĞUM
dc.subjectDahili Tıp Bilimleri
dc.subjectYaşam Bilimleri
dc.subjectEndokrinoloji
dc.subjectTıp
dc.subjectİç Hastalıkları
dc.subjectKlinik Tıp
dc.subjectEndokrinoloji ve Metabolizma Hastalıkları
dc.titleThe role of cytokeratin 19 levels in the determination of endometriosis stages
dc.typeMakale
dc.relation.journalGYNECOLOGICAL ENDOCRINOLOGY
dc.contributor.departmentSivas Cumhuriyet Üniversitesi , Tıp Fakültesi , Cerrahi Tıp Bilimleri Bölümü
dc.identifier.volume38
dc.identifier.issue10
dc.identifier.startpage879
dc.identifier.endpage884
dc.contributor.firstauthorID3455212


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