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dc.contributor.authorGuzel, Elif
dc.contributor.authorDuygu, Gonca
dc.contributor.authorKutan, Esma
dc.contributor.authorUlker, Gul Merve Yalcin
dc.contributor.authorArici, Fatma Ozen
dc.contributor.authorOzdemir, Ilkay
dc.contributor.authorBastug, Ayse Yilmaz
dc.contributor.authorÖZÇAKIR TOMRUK, CEYDA
dc.date.accessioned2023-02-21T08:40:46Z
dc.date.available2023-02-21T08:40:46Z
dc.date.issued2022
dc.identifier.citationBastug A. Y., ÖZÇAKIR TOMRUK C., Guzel E., Ozdemir I., Duygu G., Kutan E., Ulker G. M. Y., Arici F. O., "The effect of local application of thymoquinone, Nigella sativa?s bioactive component, on bone healing in experimental bone defects infected with Porphyromonas gingivalis", JOURNAL OF PERIODONTAL AND IMPLANT SCIENCE, cilt.52, sa.3, ss.206-219, 2022
dc.identifier.issn2093-2278
dc.identifier.otherav_1fbe23a9-34a3-40bc-b476-2213b25a474b
dc.identifier.othervv_1032021
dc.identifier.urihttp://hdl.handle.net/20.500.12627/186868
dc.identifier.urihttps://doi.org/10.5051/jpis.2101360068
dc.description.abstractPurpose: This study was performed to evaluate the influence of local application of thymoquinone (TQ) on bone healing in experimental bone defects infected with Porphyromonas gingivalis (PG). Methods: Forty-two female rats were randomly divided into 6 groups. A bone defect was created on the right tibia of all animals. The PG, PG/collagen membrane (COL) and PG/ TQ/COL groups were infected with PG. In the COL and PG/COL groups, the defects were covered with a COL; in the TQ/COL and PG/TQ/COL groups, the defects were covered with a TQ-containing COL. After 28 days, all animals were sacrificed. Quantitative measurements of new bone formation and osteoblast lining, as well as semiquantitative measurements of capillary density and tissue response, were analyzed. Furthermore, the presence of bacterial infections in defect areas was evaluated. Results: The new bone formation, osteoblast number, and capillary density were significantly higher in the TQ groups than in the control groups (P<0.001, P<0.001, and P<0.01, respectively). In a comparison between the TQ/COL group, with a TQ-containing COL (TQ/COL), and the PG-infected TQ-containing COL (PG/TQ/COL) group, the newly formed bone and capillary density were higher in the TQ/COL group (P<0.01). When the control group was compared to the PG, PG/COL, and PG/TQ/COL groups in terms of tissue response, the differences were statistically significant (P<0.001, P=0.02, and P=0.041, respectively). The intensity of the inflammatory cell reaction was higher in the PG, PG/COL, and PG/TQ/COL groups (P<0.05). Conclusions: Within the limitations of this study, the local application of a TQ-containing COL positively affected bone healing even if the bone defects were infected. The results suggest that TQ increased angiogenesis and showed promise for accelerating bone defect healing. Further research is warranted to support these findings and reach more definitive conclusions.
dc.language.isoeng
dc.subjectDiş Hekimliği (çeşitli)
dc.subjectTıp
dc.subjectDİŞ HEKİMLİĞİ, ORAL CERRAHİ VE TIP
dc.subjectKlinik Tıp
dc.subjectKlinik Tıp (MED)
dc.subjectSağlık Bilimleri
dc.subjectDiş Hekimliği
dc.subjectPeriodontoloji
dc.subjectOrtodonti
dc.subjectAğız Cerrahisi
dc.subjectDiş Hijyeni
dc.subjectDişçilik Hizmetleri
dc.titleThe effect of local application of thymoquinone, Nigella sativa?s bioactive component, on bone healing in experimental bone defects infected with Porphyromonas gingivalis
dc.typeMakale
dc.relation.journalJOURNAL OF PERIODONTAL AND IMPLANT SCIENCE
dc.contributor.department, ,
dc.identifier.volume52
dc.identifier.issue3
dc.identifier.startpage206
dc.identifier.endpage219
dc.contributor.firstauthorID3439643


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