Basit öğe kaydını göster

dc.contributor.authorSekitmen, Gozde Bayazit
dc.contributor.authorOkay, Oğuz
dc.contributor.authorDiken Gür, Sinem
dc.contributor.authorİde, Semra
dc.contributor.authorSu, Esra
dc.date.accessioned2023-02-21T08:53:01Z
dc.date.available2023-02-21T08:53:01Z
dc.identifier.citationSekitmen G. B., Su E., Diken Gür S., İde S., Okay O., "Sterilization studies of hydrogel nanocomposites designed for possible biomedical applications before in vivo research", REACTIVE & FUNCTIONAL POLYMERS, cilt.180, 2022
dc.identifier.issn1381-5148
dc.identifier.othervv_1032021
dc.identifier.otherav_23b4e8b3-4a2c-4006-bb2c-a5e3006b0e8d
dc.identifier.urihttp://hdl.handle.net/20.500.12627/187043
dc.identifier.urihttps://doi.org/10.1016/j.reactfunctpolym.2022.105393
dc.description.abstractThis study emphasized the importance of hydrogel-based therapy in repairing cartilage tissue and discussed the nanoscopic requirements for the physical sterilization of hydrogels, which are repairable, biochemically compatible with cartilage structure, and shape memory under mechanical effects.The nanostructured and the shape memory hydrogel composites, previously designed, synthesized, and nano -structurally characterized by our group, were used as material in the present study. Samples are including poly (N,N-dimethylacrylamide) (poly (DMAA) chains, n-octadecyl acrylate (C18A) segments and with/without lauryl methacrylate (LM).The study consists of four main sections in which physical sterilization processes (with electromagnetic waves from low energy (UV) to high energy (X-ray and Gamma-ray) are applied, structural changes are determined at microscopic and nanoscopic scale, and biofilm formations in the mentioned hydrogel materials are evaluated.The present study investigated these hydrogels' potential as artificial cartilage or cartilage tissue scaffolds. To initiate in vivo studies, it was aimed to determine the most appropriate physical sterilization method.In the result of the study, the most convenient hydrogel sample for surgical (in vivo) research, the useful physical sterilization methods, and the ability to resist biofilm formation was determined for the sample of N:3, [DMMA/C18A/LM, (70/30/0.0) l (Pre stretching ratio) = 1.8]. UV applications were also determined as the most generally suitable sterilization method for these hydrogels. As the pre-stretching ratio increases, the emergence of more compact and globular nano formations in hydrogel structures also affects the bioactive properties. It was also shown that, with the help of the usage of energetic electromagnetic waves for sterilizations, the new 3D nano aggregation morphologies might be created in the hydrogel structures.
dc.language.isoeng
dc.subjectKimya Mühendisliği ve Teknolojisi
dc.subjectFizikokimya
dc.subjectPolimer Karakterizasyonu
dc.subjectDiğer
dc.subjectTemel Bilimler
dc.subjectMühendislik ve Teknoloji
dc.subjectPolimerler ve Plastikler
dc.subjectGenel Mühendislik
dc.subjectMühendislik (çeşitli)
dc.subjectKimya (çeşitli)
dc.subjectGenel Kimya
dc.subjectProses Kimyası ve Teknolojisi
dc.subjectAkışkan Akışı ve Transfer İşlemleri
dc.subjectKolloid ve Yüzey Kimyası
dc.subjectKimyasal Sağlık ve Güvenlik
dc.subjectMühendislik, Bilişim ve Teknoloji (ENG)
dc.subjectKimya Mühendisliği (çeşitli)
dc.subjectGenel Kimya Mühendisliği
dc.subjectFizik Bilimleri
dc.subjectKataliz
dc.subjectPOLİMER BİLİMİ
dc.subjectMühendislik
dc.subjectMÜHENDİSLİK, KİMYASAL
dc.subjectTemel Bilimler (SCI)
dc.subjectKimya
dc.subjectKİMYA, UYGULAMALI
dc.titleSterilization studies of hydrogel nanocomposites designed for possible biomedical applications before in vivo research
dc.typeMakale
dc.relation.journalREACTIVE & FUNCTIONAL POLYMERS
dc.contributor.departmentİstanbul Üniversitesi , Su Bilimleri Fakültesi , Akuatik Biyoteknoloji ve Genomik Bölümü
dc.identifier.volume180
dc.contributor.firstauthorID4068833


Bu öğenin dosyaları:

DosyalarBoyutBiçimGöster

Bu öğe ile ilişkili dosya yok.

Bu öğe aşağıdaki koleksiyon(lar)da görünmektedir.

Basit öğe kaydını göster