Ripple-selective GABAergic projection cells in the hippocampus
Date
2022Author
Gulsever, Cafer İkbal
Varga, Csaba
Gschwind, Tilo
Moolchand, Prannath
Soltesz, Ivan
Szabo, Gergely G.
Farrell, Jordan S.
Dudok, Barna
Hou, Wen-Hsien
Ortiz, Anna L.
Capogna, Marco
Dimidschstein, Jordane
Metadata
Show full item recordAbstract
Ripples are brief high-frequency electrographic events with important roles in episodic memory. However, the in vivo circuit mechanisms coordinating ripple-related activity among local and distant neuronal ensembles are not well understood. Here, we define key characteristics of a long-distance projecting GABAergic cell group in the mouse hippocampus that selectively exhibits high-frequency firing during ripples while staying largely silent during theta-associated states when most other GABAergic cells are active. The high ripple associated firing commenced before ripple onset and reached its maximum before ripple peak, with the signature theta-OFF, ripple-ON firing pattern being preserved across awake and sleep states. Controlled by septal GABAergic, cholinergic, and CA3 glutamatergic inputs, these ripple-selective cells innervate parvalbumin and cholecystokinin-expressing local interneurons while also targeting a variety of extra-hippocampal regions. These results demonstrate the existence of a hippocampal GABAergic circuit element that is uniquely positioned to coordinate ripple-related neuronal dynamics across neuronal assemblies.
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