dc.contributor.author | Yilmaz, Melda Yardimoglu | |
dc.contributor.author | Kokturk, Sibel | |
dc.contributor.author | Balikci, Aymen | |
dc.contributor.author | ATEŞ, NURBAY | |
dc.contributor.author | BALCİ, SİBEL | |
dc.contributor.author | BAYDEMİR, CANAN | |
dc.contributor.author | İLBAY, GÜL | |
dc.date.accessioned | 2023-02-21T09:29:24Z | |
dc.date.available | 2023-02-21T09:29:24Z | |
dc.identifier.citation | İLBAY G., Balikci A., Kokturk S., Yilmaz M. Y., ATEŞ N., BAYDEMİR C., BALCİ S., "Neonatal Tactile Stimulation Downregulates Dendritic Spines in Layer V Pyramidal Neurons of the WAG/Rij Rat Somatosensory Cortex", NEURAL PLASTICITY, cilt.2022, 2022 | |
dc.identifier.issn | 2090-5904 | |
dc.identifier.other | vv_1032021 | |
dc.identifier.other | av_2f341876-8275-4c64-b026-8217b31de637 | |
dc.identifier.uri | http://hdl.handle.net/20.500.12627/187529 | |
dc.identifier.uri | https://doi.org/10.1155/2022/7251460 | |
dc.identifier.uri | https://avesis.istanbul.edu.tr/api/publication/2f341876-8275-4c64-b026-8217b31de637/file | |
dc.description.abstract | Objective. The aim of our study is to examine the effects of neonatal tactile stimulations on the brain structures that previously defined as the focus of epilepsy in the Wistar-Albino-Glaxo from Rijswijk (WAG/Rij) rat brain with genetic absence epilepsy. Methods. In the present research, morphology and density of dendritic spines were analyzed in layer V pyramidal neurons of the somatosensory cortex (SoCx) of WAG/Rij rats (nonstimulated control, tactile-stimulated, and maternal separated rats) and healthy Wistar (nonepileptic) rats. To achieve this, a Golgi-Cox method was used. Results. Dendritic spine number in layer V of the SoCx has been detected significantly higher in adult WAG/Rij rats at postnatal day 150 in comparison to nonepileptic adult control Wistar rats (p < 0.001). Moreover, quantitative analyses of dendrite structure in adult WAG/Rij rats showed a decrease in dendrite spine density of pyramidal neurons of SoCx which occurred in early neonatal exposure to maternal separation (MS) and tactile stimulation (TS) (p < 0.001). Conclusions. Our findings provide the first evidence that tactile stimulations during the early postnatal period have a long-term impact on dendrite structure in WAG/Rij rat's brain and demonstrate that neonatal tactile stimulation can regulate dendritic spines in layer V in pyramidal neurons of SoCx in epileptic brains. | |
dc.language.iso | eng | |
dc.subject | Cognitive Neuroscience | |
dc.subject | General Neuroscience | |
dc.subject | Neuroscience (miscellaneous) | |
dc.subject | Sensory Systems | |
dc.subject | Human-Computer Interaction | |
dc.subject | Physical Sciences | |
dc.subject | Life Sciences | |
dc.subject | Developmental Neuroscience | |
dc.subject | Cellular and Molecular Neuroscience | |
dc.subject | Temel Bilimler | |
dc.subject | Yaşam Bilimleri | |
dc.subject | Yaşam Bilimleri (LIFE) | |
dc.subject | Sinirbilim ve Davranış | |
dc.subject | SİNİR BİLİMİ | |
dc.title | Neonatal Tactile Stimulation Downregulates Dendritic Spines in Layer V Pyramidal Neurons of the WAG/Rij Rat Somatosensory Cortex | |
dc.type | Makale | |
dc.relation.journal | NEURAL PLASTICITY | |
dc.contributor.department | Kocaeli Üniversitesi , Tıp Fakültesi , Temel Tıp Bilimleri | |
dc.identifier.volume | 2022 | |
dc.contributor.firstauthorID | 3434659 | |