dc.contributor.author | Çevik, Aydın | |
dc.contributor.author | Solakoğlu, Seyhun | |
dc.contributor.author | Akdeniz, Nilgün | |
dc.contributor.author | Öncül, Mustafa Oral | |
dc.contributor.author | Deniz, Günnur | |
dc.contributor.author | Öktelik, Fatma Betül | |
dc.contributor.author | Öztürk Civelek, Dilek | |
dc.contributor.author | Okyar, Alper | |
dc.contributor.author | Çetin, Esin | |
dc.contributor.author | Küçüksezer, Umut Can | |
dc.date.accessioned | 2023-02-21T09:56:30Z | |
dc.date.available | 2023-02-21T09:56:30Z | |
dc.date.issued | 2022 | |
dc.identifier.citation | Öktelik F. B., Öztürk Civelek D., Okyar A., Çetin E., Küçüksezer U. C., Akdeniz N., Solakoğlu S., Çevik A., Öncül M. O., Deniz G., "Evaluation of the Immunomodulatory Effects of C-Vx on the Innate and Adaptive "Immune" System: Preliminary Results", JOURNAL OF COMPLEMENTARY MEDICINE RESEARCH, cilt.13, sa.3, ss.135-144, 2022 | |
dc.identifier.issn | 2577-5669 | |
dc.identifier.other | vv_1032021 | |
dc.identifier.other | av_3888595a-3fba-4f64-a194-be8de9dc5fdc | |
dc.identifier.uri | http://hdl.handle.net/20.500.12627/187943 | |
dc.identifier.uri | https://avesis.istanbul.edu.tr/api/publication/3888595a-3fba-4f64-a194-be8de9dc5fdc/file | |
dc.identifier.uri | https://doi.org/10.5455/jcmr.2022.13.03.29 | |
dc.description.abstract | AbstractObjectives: In this preliminary study, the in vitro effect of C-Vx in human PBMCs and the in vivo effect of C-Vx in rats were investigated.Methods: The human part was analyzed in PBMCs isolated from healthy subjects. Apoptotic index, cytotoxic activity of CD8+ T and NK cells, and cell proliferation of CD3+, CD4+, CD8+ T and NK cells in response to different doses of C-Vx were investigated. Also the hematological and biochemical parameters of the rats administered subcutaneously in three different doses of C-Vx were monitored for 14-days.Results: Increased CD107a expression in response to C-Vx on NK cells but not on CD8+ T cells support the increasing of NK cell cytotoxicity. C-Vx alone was capable of triggering proliferation of T and NK cells. The PHA-induced proliferation of CD3+ and CD4+ T cells was diminished in response to C-Vx, while PHA-induced CD8+ T cell proliferation was up-regulated. PHA-triggered proliferation of total NK cells was enhanced with the existence of C-Vx.C-Vx was well tolerated in rats with no serious adverse effects or mortality (death) after 14-days of follow-up. Biochemical-parameters (creatinine, blood urea nitrogen, etc.) were not significantly different among treated and control groups. The levels of white blood cells and lymphocytes were increased up to two-folds in the C-Vx group (especially 0.25 ml/day) as compared to the control group.Conclusion: Taken together, these preliminary findings support the immunomodulatory effects of C-Vx. But these findings should cautiously be evaluated due to the low numbers of subjects in both human and experimental arms.Key words:Cytotoxicity, immunomodulator, immune cells, viral infection | |
dc.language.iso | eng | |
dc.subject | Klinik Tıp (MED) | |
dc.subject | Sağlık Bilimleri | |
dc.title | Evaluation of the Immunomodulatory Effects of C-Vx on the Innate and Adaptive "Immune" System: Preliminary Results | |
dc.type | Makale | |
dc.relation.journal | JOURNAL OF COMPLEMENTARY MEDICINE RESEARCH | |
dc.contributor.department | İstanbul Üniversitesi , Aziz Sancar Deneysel Tıp Araştırma Enstitüsü , İmmünoloji Ana Bilim Dalı | |
dc.identifier.volume | 13 | |
dc.identifier.issue | 3 | |
dc.identifier.startpage | 135 | |
dc.identifier.endpage | 144 | |
dc.contributor.firstauthorID | 4234295 | |