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dc.contributor.authorDUMAN, NİLGÜN
dc.contributor.authorUyanik, Bulent
dc.contributor.authorErdogan, Murat
dc.contributor.authorBalta, Burhan
dc.contributor.authorKiraz, Aslihan
dc.contributor.authorSag, Sebnem Ozemri
dc.contributor.authorTUĞ BOZDOĞAN, SEVCAN
dc.contributor.authorBİŞGİN, ATIL
dc.contributor.authorTuncel, Gulten
dc.contributor.authorGÜL, Şeref
dc.contributor.authorAtes, Esra Arslan
dc.contributor.authorAlavanda, Ceren
dc.contributor.authorOzdemir, Sevda Yesim
dc.contributor.authorSezer, Ozlem
dc.contributor.authorOzgon, Gulay Oner
dc.contributor.authorGurkan, Hakan
dc.contributor.authorGuler, Kubra
dc.contributor.authorBoga, Ibrahim
dc.contributor.authorKaya, Niyazi
dc.contributor.authorAlemdar, Adem
dc.contributor.authorSayan, Murat
dc.contributor.authorDundar, Munis
dc.contributor.authorErgoren, Mahmut Cerkez
dc.contributor.authorTemel, Sehime Gulsun
dc.contributor.authorGeckinli, Bilgen Bilge
dc.contributor.authorAta, Pinar
dc.contributor.authorCanbek, Sezin
dc.date.accessioned2023-02-21T10:17:44Z
dc.date.available2023-02-21T10:17:44Z
dc.date.issued2022
dc.identifier.citationDUMAN N., Tuncel G., BİŞGİN A., TUĞ BOZDOĞAN S., Sag S. O., GÜL Ş., Kiraz A., Balta B., Erdogan M., Uyanik B., et al., "Analysis of ACE2 and TMPRSS2 coding variants as a risk factor for SARS-CoV-2 from 946 whole-exome sequencing data in the Turkish population", JOURNAL OF MEDICAL VIROLOGY, cilt.94, sa.11, ss.5225-5243, 2022
dc.identifier.issn0146-6615
dc.identifier.othervv_1032021
dc.identifier.otherav_4125fd76-79b7-42c3-9431-1d963a23f39c
dc.identifier.urihttp://hdl.handle.net/20.500.12627/188280
dc.identifier.urihttps://doi.org/10.1002/jmv.27976
dc.description.abstractHeterogeneity in symptoms associated with COVID-19 in infected patients remains unclear. ACE2 and TMPRSS2 gene variants are considered possible risk factors for COVID-19. In this study, a retrospective comparative genome analysis of the ACE2 and TMPRSS2 variants from 946 whole-exome sequencing data was conducted. Allele frequencies of all variants were calculated and filtered to remove variants with allele frequencies lower than 0.003 and to prioritize functional coding variants. The majority of detected variants were intronic, only two ACE2 and three TMPRSS2 nonsynonymous variants were detected in the analyzed cohort. The main ACE2 variants that putatively have a protective or susceptibility effect on SARS-CoV-2 have not yet been determined in the Turkish population. The Turkish genetic makeup likely lacks any ACE2 variant that increases susceptibility to SARS-CoV-2 infection. TMPRSS2 rs75603675 and rs12329760 variants that were previously defined as common variants that have different allele frequencies among populations and may have a role in SARS-CoV-2 attachment to host cells were determined in the population. Overall, these data will contribute to the formation of a national variation database and may also contribute to further studies of ACE2 and TMPRSS2 in the Turkish population and differences in SARS-CoV-2 infection among other populations.
dc.language.isoeng
dc.subjectTemel Tıp Bilimleri
dc.subjectTemel Bilimler
dc.subjectYaşam Bilimleri
dc.subjectViroloji
dc.subjectMikrobiyoloji ve Klinik Mikrobiyoloji
dc.subjectSağlık Bilimleri
dc.subjectTıp
dc.subjectYaşam Bilimleri (LIFE)
dc.subjectİmmünoloji
dc.subjectVİROLOJİ
dc.subjectGenel İmmünoloji ve Mikrobiyoloji
dc.titleAnalysis of ACE2 and TMPRSS2 coding variants as a risk factor for SARS-CoV-2 from 946 whole-exome sequencing data in the Turkish population
dc.typeMakale
dc.relation.journalJOURNAL OF MEDICAL VIROLOGY
dc.contributor.departmentİstanbul Üniversitesi , Fen Fakültesi , Biyoloji Bölümü
dc.identifier.volume94
dc.identifier.issue11
dc.identifier.startpage5225
dc.identifier.endpage5243
dc.contributor.firstauthorID3441720


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