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dc.contributor.authorYılmaz, Umit
dc.contributor.authorSANDAL, SÜLEYMAN
dc.contributor.authorKOÇ, AHMET
dc.contributor.authorTANBEK, KEVSER
dc.contributor.authorGÜL, MEHMET
dc.date.accessioned2023-02-21T10:18:52Z
dc.date.available2023-02-21T10:18:52Z
dc.identifier.citationTANBEK K., Yılmaz U., GÜL M., KOÇ A., SANDAL S., "Effects of central FGF21 infusion on the glucose homeostasis in rats (brain–pancreas axis)", Archives of Physiology and Biochemistry, 2023
dc.identifier.issn1381-3455
dc.identifier.othervv_1032021
dc.identifier.otherav_418c2a30-e2e5-4db6-a636-85e8f2530837
dc.identifier.urihttp://hdl.handle.net/20.500.12627/188291
dc.identifier.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85146344658&origin=inward
dc.identifier.urihttps://doi.org/10.1080/13813455.2023.2166964
dc.description.abstract© 2023 Informa UK Limited, trading as Taylor & Francis Group.Introduction: Glucose homeostasis is a physiological process mediated by a variety of hormones. Fibroblast growth factor (FGF) 21 is a protein expressed in the liver, adipose tissue, muscle and pancreas and exerts actions in multiple targets including adipose, liver, pancreas and hypothalamus. The aim of this study was to examine the possible involvement of FGF21 in pancreatic and central control of glucose by measuring reflective changes in the release of insulin and glucagon. Methods: Thirty adult male Wistar Albino rats were divided; Control, PD + aCSF, PD + FGF21 groups (n = 10). Effects of intracerebroventricular (icv) FGF21 administration to pancreatic denervated (PD) rats. Agouti-related protein (AgRP), Pro-opiomelanocortin (POMC) levels and blood glucose homeostasis were investigated. Results: Administration of FGF21 to 3rd ventricle increased food consumption but body weight didn’t change significantly. AgRP level increased, pancreatic insulin levels increased, and glucagon level decreased. Conclusion: Central FGF21 administration is effective in regulating blood glucose homeostasis by increasing the amount and efficiency of insulin and changing glucose use.
dc.language.isoeng
dc.subjectBiyokimya
dc.subjectFizyoloji
dc.subjectTemel Bilimler
dc.subjectFizyoloji (tıbbi)
dc.subjectSağlık Bilimleri
dc.subjectTemel Tıp Bilimleri
dc.subjectYaşam Bilimleri
dc.subjectTıp
dc.subjectFİZYOLOJİ
dc.subjectBiyoloji ve Biyokimya
dc.subjectYaşam Bilimleri (LIFE)
dc.titleEffects of central FGF21 infusion on the glucose homeostasis in rats (brain–pancreas axis)
dc.typeMakale
dc.relation.journalArchives of Physiology and Biochemistry
dc.contributor.departmentİnönü Üniversitesi , Tıp Fakültesi , Temel Tıp Bilimleri
dc.contributor.firstauthorID4245581


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