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dc.contributor.authorKocak, Elif N.
dc.contributor.authorNajafzadeh, Parisa
dc.contributor.authorSangoi, Ankur
dc.contributor.authorPattnaik, Niharika
dc.contributor.authorMishra, Sourav
dc.contributor.authorBaisakh, Manas
dc.contributor.authorLightle, Andrea R.
dc.contributor.authorBalzer, Bonnie L.
dc.contributor.authorXiao, Guang-Qian
dc.contributor.authorMacLennan, Gregory T.
dc.contributor.authorOsunkoya, Adeboye O.
dc.contributor.authorParwani, Anil
dc.contributor.authorCheng, Liang
dc.contributor.authorBellizzi, Andrew
dc.contributor.authorMohanty, Sambit K.
dc.contributor.authorAkgul, Mahmut
dc.contributor.authorHumble, Robert
dc.contributor.authorOsme, Abdullah
dc.contributor.authorYuce, Servet
dc.contributor.authorSharma, Shivani
dc.contributor.authorShaker, Nada
dc.contributor.authorKaushal, Seema
dc.date.accessioned2023-02-21T10:22:05Z
dc.date.available2023-02-21T10:22:05Z
dc.date.issued2022
dc.identifier.citationAkgul M., Humble R., Osme A., Yuce S., Kocak E. N., Najafzadeh P., Sangoi A., Pattnaik N., Mishra S., Sharma S., et al., "GATA3 expression in clear cell adenocarcinoma of the lower urinary tract: a potential diagnostic pitfall", DIAGNOSTIC PATHOLOGY, cilt.17, sa.1, 2022
dc.identifier.issn1746-1596
dc.identifier.othervv_1032021
dc.identifier.otherav_429ac3ea-1dac-40c8-87ba-631ee604909b
dc.identifier.urihttp://hdl.handle.net/20.500.12627/188346
dc.identifier.urihttps://doi.org/10.1186/s13000-022-01269-6
dc.identifier.urihttps://avesis.istanbul.edu.tr/api/publication/429ac3ea-1dac-40c8-87ba-631ee604909b/file
dc.description.abstractBackground Clear cell adenocarcinoma of the lower urinary tract (CCACLUT) is a rare primary malignant neoplasm with heterogenous morphology. There is a paucity of data in the literature regarding its immunohistochemical profile. Methods The immunohistochemical features (extent and intensity) of a multinational cohort of CCACLUT were evaluated with comparison between clear cell adenocarcinoma of the female genital tract (CCACFGT, tissue microarray) and nephrogenic adenoma (NA). Results 33 CCACLUT (24 female, 9 male; mean age 59 years) were collected. CCACLUT most commonly arose from the urinary bladder (26/33, 78%), particularly from the trigone (10/33, 30.3%) followed by the urethra (8/33, 22%). All 12 NA cases were located at the urinary bladder, whereas the most common CCACFGT location was the ovary (29/56, 52%). None of the CCACLUT patients had, intestinal metaplasia, NA, or urothelial carcinoma. One patient had concurrent endometriosis of the sigmoid colon. Most frequently observed morphology in CCACLUT was papillary/tubulocystic (9/3; 27.3%), followed by papillary/tubular (6/33; 18.2%) and papillary/solid (5/33; 15.2%). GATA3 expression was significantly higher in CCACLUT (18/33, 54.5%) and NA (6/12, 50%), when compared to CCACFGT cases 6/56, 11.7%)(p = 0.001 and p = 0.022, respectively). The extent of GATA3 was significantly higher in CCACLUT group (19.2 +/- 16.6%) than the other groups (9.6 +/- 22.5% in NA and 2.6 +/- 9% in CCACFGT group) (p = 0.001). 4/33 patients (12.1) had weak, 10/33 patients (30.3%) had moderate, and 4/33 patients (12.1%) had strong GATA3 intensity in CCACLUT group. In NA group, one patient (8.3%, 1/12) had weak, one patient (8.3%, 1/12) had moderate and 4 patients (33.3%, 4/12) had strong GATA3 intensity. Most cases (CCACLUT 29/33, 88%; NA 11/12, 92%; CCACFGT 46/56, 82.1%) had positive Napsin A expression, by which CCACLUT had significantly more cases with Napsin A expression (p = 0.034). p63 was consistently negative in all cases (30/33 (91.9%) CCACLUT; 12/12 (100%) NA; 42/56 (75%) CCACFGT. Ki67 (MIB) proliferation index was significantly higher in CCACLUT group (54.6 +/- 21%) when compared to NA group (4.5 +/- 2.7%) and CCACFGT group (35.5 +/- 25.8%) (p = 0.001). Conclusion CCACLUT has consistent GATA3 expression, which may cause challenge in the diagnosis of urothelial carcinoma but can be used to distinguish CCACLUT from CCACFGT.
dc.language.isoeng
dc.subjectTemel Tıp Bilimleri
dc.subjectPATOLOJİ
dc.subjectBiyoloji ve Biyokimya
dc.subjectYaşam Bilimleri (LIFE)
dc.subjectTıp
dc.subjectCerrahi Tıp Bilimleri
dc.subjectPatoloji
dc.subjectYaşam Bilimleri
dc.subjectSağlık Bilimleri
dc.subjectBiyokimya
dc.subjectTemel Bilimler
dc.subjectPatoloji ve Adli Tıp
dc.subjectHistoloji
dc.subjectBiyokimya (tıbbi)
dc.titleGATA3 expression in clear cell adenocarcinoma of the lower urinary tract: a potential diagnostic pitfall
dc.typeMakale
dc.relation.journalDIAGNOSTIC PATHOLOGY
dc.contributor.departmentAlbany Med Ctr , ,
dc.identifier.volume17
dc.identifier.issue1
dc.contributor.firstauthorID4075978


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