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dc.contributor.authorGünbatan, Murat
dc.contributor.authorÖzcakir-Tomruk, Ceyda
dc.contributor.authorDuygu, Gonca
dc.contributor.authorSOLUK TEKKEŞİN, MERVA
dc.contributor.authorYalcin-Ülker, Gül Merve
dc.date.accessioned2023-05-29T10:48:58Z
dc.date.available2023-05-29T10:48:58Z
dc.date.issued2023
dc.identifier.citationYalcin-Ülker G. M., Günbatan M., Duygu G., SOLUK TEKKEŞİN M., Özcakir-Tomruk C., "Could Local Application of Hypoxia Inducible Factor 1-α Enhancer Deferoxamine Be Promising for Preventing of Medication-Related Osteonecrosis of the Jaw?", Biomedicines, cilt.11, sa.3, 2023
dc.identifier.issn2227-9059
dc.identifier.othervv_1032021
dc.identifier.otherav_00db5ff1-62c0-48eb-9659-707697c76439
dc.identifier.urihttp://hdl.handle.net/20.500.12627/188590
dc.identifier.urihttps://avesis.istanbul.edu.tr/api/publication/00db5ff1-62c0-48eb-9659-707697c76439/file
dc.identifier.urihttps://doi.org/10.3390/biomedicines11030758
dc.description.abstractThis experimental study investigates the prophylactic effect of deferoxamine (DFO) on medication-related osteonecrosis of the jaw (MRONJ). Thirty-six female Sprague Dawley rats received zoledronic acid (ZA) for eight weeks to create an osteonecrosis model. DFO was locally applied into the extraction sockets with gelatin sponge (GS) carriers to prevent MRONJ. The specimens were histopathologically and histomorphometrically evaluated. Hypoxia-inducible factor 1-alpha (HIF-1α) protein levels in the extraction sockets were quantified. New bone formation rate differed significantly between groups (p = 0.005). Newly formed bone ratios in the extraction sockets did not differ significantly between the control group and the GS (p = 1), GS/DFO (p = 0.749), ZA (p = 0.105), ZA-GS (p = 0.474), and ZA-GS/DFO (p = 1) groups. While newly formed bone rates were higher in the ZA-GS and ZA-GS/DFO groups than in the ZA group, the differences were not significant. HIF-1α levels differed significantly between groups (p < 0.001) and were significantly higher in the DFO and ZA-GS/DFO groups than in the control group (p = 0.001 and p = 0.004, respectively). While HIF-1α levels were higher in the ZA-GS/DFO group than in the ZA group, the difference was not significant. While HIF-1α protein levels and new bone formation rate were elevated in the DFO-treated group, the effect was not significant. Further large-scale studies are needed to understand DFO’s preventative effects on MRONJ and the role of HIF-1α in MRONJ pathogenesis.
dc.language.isoeng
dc.subjectSağlık Bilimleri
dc.subjectTemel Tıp Bilimleri
dc.subjectTemel Bilimler
dc.subjectTıp (çeşitli)
dc.subjectGenel Biyokimya, Genetik ve Moleküler Biyoloji
dc.subjectYaşam Bilimleri
dc.subjectSitogenetik
dc.subjectTıp
dc.subjectBİYOKİMYA VE MOLEKÜLER BİYOLOJİ
dc.subjectTIP, GENEL & DAHİLİ
dc.subjectMoleküler Biyoloji ve Genetik
dc.subjectKlinik Tıp
dc.subjectYaşam Bilimleri (LIFE)
dc.subjectKlinik Tıp (MED)
dc.titleCould Local Application of Hypoxia Inducible Factor 1-α Enhancer Deferoxamine Be Promising for Preventing of Medication-Related Osteonecrosis of the Jaw?
dc.typeMakale
dc.relation.journalBiomedicines
dc.contributor.departmentOkan Üniversitesi , ,
dc.identifier.volume11
dc.identifier.issue3
dc.contributor.firstauthorID4263241


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