Localization Techniques for Non-Palpable Breast Lesions: Current Status, Knowledge Gaps, and Rationale for the MELODY Study (EUBREAST-4/iBRA-NET, NCT 05559411)
Tarih
2023Yazar
Smidt, Marjolein
Gulluoglu, Bahadir M.
Krawczyk, Natalia
Aktas Sezen, Bilge
Weber, Walter Paul
Harvey, James
Lux, Michael Patrick
Murawa, Dawid
Banys-Paluchowski, Maggie
Kühn, Thorsten
Masannat, Yazan
Rubio, Isabel
de Boniface, Jana
Ditsch, Nina
Karadeniz Cakmak, Güldeniz
Karakatsanis, Andreas
Dave, Rajiv
Hahn, Markus
Potter, Shelley
Kothari, Ashutosh
Gentilini, Oreste Davide
Gasparri, Maria Luisa
Canturk, Nuh Zafer
Cabioglu, Neslihan
Malherbe, Francois
Nietz, Sarah
Di Micco, Rosa
Hartmann, Steffi
Üst veri
Tüm öğe kaydını gösterÖzet
Background: Surgical excision of a non-palpable breast lesion requires a localization step. Among available techniques, wire-guided localization (WGL) is most commonly used. Other techniques (radioactive, magnetic, radar or radiofrequency-based, and intraoperative ultrasound) have been developed in the last two decades with the aim of improving outcomes and logistics. Methods: We performed a systematic review on localization techniques for non-palpable breast cancer. Results: For most techniques, oncological outcomes such as lesion identification and clear margin rate seem either comparable with or better than for WGL, but evidence is limited to small cohort studies for some of the devices. Intraoperative ultrasound is associated with significantly higher negative margin rates in meta-analyses of randomized clinical trials (RCTs). Radioactive techniques were studied in several RCTs and are non-inferior to WGL. Smaller studies show higher patient preference towards wire-free localization, but little is known about surgeons’ and radiologists’ attitudes towards these techniques. Conclusions: Large studies with an additional focus on patient, surgeon, and radiologist preference are necessary. This review aims to present the rationale for the MELODY (NCT05559411) study and to enable standardization of outcome measures for future studies.
Bağlantı
http://hdl.handle.net/20.500.12627/188897https://doi.org/10.3390/cancers15041173
https://avesis.istanbul.edu.tr/api/publication/233e6b2c-194e-4111-a31d-1c54db9f7c05/file
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