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dc.contributor.authorSözeri, Betül
dc.contributor.authorŞahin, Nihal
dc.contributor.authorDemir, Ferhat
dc.contributor.authorBağlan, Esra
dc.contributor.authorKara, Mehtap Akbalık
dc.contributor.authorSelçuk, Şenay Zırhlı
dc.contributor.authorÖzdel, Semanur
dc.contributor.authorÇomak, Elif
dc.contributor.authorAkkoyunlu, Betül
dc.contributor.authorYener, Gülçin Otar
dc.contributor.authorYıldırım, Deniz Gezgin
dc.contributor.authorÖztürk, Kübra
dc.contributor.authorYıldız, Mehmet
dc.contributor.authorHaşlak, Fatih
dc.contributor.authorŞener, Seher
dc.contributor.authorKısaoğlu, Hakan
dc.contributor.authorBaba, Özge
dc.contributor.authorKızıldağ, Zehra
dc.contributor.authorİşgüder, Rana
dc.contributor.authorÇağlayan, Şengül
dc.contributor.authorBilgin, Raziye B. Güven
dc.contributor.authorAytaç, Gülçin
dc.contributor.authorYücel, Burcu Bozkaya
dc.contributor.authorTanatar, Ayşe
dc.contributor.authorSönmez, Hafize E.
dc.contributor.authorÇakan, Mustafa
dc.contributor.authorKara, Aslıhan
dc.contributor.authorElmas, Ahmet T.
dc.contributor.authorKılıç, Beltinge Demircioğlu
dc.contributor.authorAyaz, Nuray Aktay
dc.contributor.authorKasap, Belde
dc.contributor.authorKısaarslan, Ayşenur Paç
dc.contributor.authorÇiçek, Sümeyra Özdemir
dc.contributor.authorBATU AKAL, EZGİ DENİZ
dc.contributor.authorŞahin, Sezgin
dc.contributor.authorGürgöze, Metin K.
dc.contributor.authorBARUT, KENAN
dc.contributor.authorAcar, Banu Çelikel
dc.contributor.authorOzkaya, Ozan
dc.contributor.authorYüksel, Selçuk
dc.contributor.authorBakkaloğlu, Sevcan
dc.contributor.authorAydoğ, Özlem
dc.contributor.authorAksu, Güzide
dc.contributor.authorAkman, Sema
dc.contributor.authorDönmez, Osman
dc.contributor.authorBülbül, Mehmet
dc.contributor.authorBüyükçelik, Mithat
dc.contributor.authorTabel, Yılmaz
dc.contributor.authorKalyoncu, Mukaddes
dc.contributor.authorBilginer, Yelda
dc.contributor.authorPoyrazoğlu, Muammer H.
dc.contributor.authorÜnsal, Erbil
dc.contributor.authorKasapçopur, Özgür
dc.contributor.authorÖzen, Seza
dc.contributor.authorDüşünsel, Ruhan
dc.contributor.authorÇetinkaya, Sibel Balcı
dc.contributor.authorEkinci, Miray Kışla
dc.contributor.authorATMIŞ, BAHRİYE
dc.contributor.authorAdrovic, Amra
dc.contributor.authorAğar, Buket Esen
dc.date.accessioned2023-05-29T13:47:07Z
dc.date.available2023-05-29T13:47:07Z
dc.date.issued2023
dc.identifier.citationKısaarslan A. P., Çiçek S. Ö., BATU AKAL E. D., Şahin S., Gürgöze M. K., Çetinkaya S. B., Ekinci M. K., ATMIŞ B., BARUT K., Adrovic A., et al., "Neuropsychiatric involvement in juvenile-onset systemic lupus erythematosus: A multicenter study", Joint Bone Spine, cilt.90, sa.4, 2023
dc.identifier.issn1297-319X
dc.identifier.othervv_1032021
dc.identifier.otherav_3d15f48e-bb9a-49d2-a99b-4692b7d45edc
dc.identifier.urihttp://hdl.handle.net/20.500.12627/189112
dc.identifier.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85150809280&origin=inward
dc.identifier.urihttps://doi.org/10.1016/j.jbspin.2023.105559
dc.description.abstractIntroduction: Neuropsychiatric (NP) involvement is a restricted area in juvenile-onset systemic lupus erythematosus (jSLE). Aim: To investigate the prevalence, demographic and clinical features, and outcomes of the neurological involvement in the Turkish jSLE population. Methods: This study was based upon 24 referral centers’ SLE cohorts, multicenter and multidisciplinary network in Turkey. Patient data were collected by a case report form which was standardized for NP definitions according to American Collage of Rheumatology (ACR). Systemic Lupus International Collaborating Clinics/American College of Rheumatology Damage Index (SDI) neuropsychiatric part was used to determine NP damage. Variables were evaluated Ward's hierarchical clustering analyses, univariate, and multivariate logistic regression analyses. Results: A hundred forty-nine of 1107 jSLE patients had NP involvement (13.5%). The most common NPSLE findings were headache (50.3%), seizure (38.3%), and acute confusional state (33.6%). Five clusters were identified with all clinical and laboratory findings. The first two clusters involved neuropathies, demyelinating diseases, aseptic meningitis, and movement disorder. Cluster 3 involved headache, activity markers and other SLE involvements. Idiopathic intracranial hypertension, cerebrovascular disease, cognitive dysfunction, psychiatric disorders and SLE antibodies were in the fourth, and acute confusional state was in the fifth cluster. In multivariate analysis, APA positivity; OR: 2.820, (%95CI: 1.002–7.939), P: 0,050, plasmapheresis; OR: 13.804 (%95CI: 2.785–68.432), P: 0,001, SLEDAI scores; OR: 1.115 (%95CI: (1.049–1.186), P: 0,001 were associated with increased risk for neurologic sequelae. Conclusion: We detected the prevalence of juvenile NPSLE manifestations in Turkey. We have identified five clusters that may shed light pathogenesis, treatment and prognosis of NP involvements. We also determined risk factors of neurological sequelae. Our study showed that new definitions NP involvements and sequelae for childhood period are needed.
dc.language.isoeng
dc.subjectKlinik Tıp (MED)
dc.subjectTıp
dc.subjectROMATOLOJİ
dc.subjectKlinik Tıp
dc.subjectDahili Tıp Bilimleri
dc.subjectİç Hastalıkları
dc.subjectİmmünoloji ve Romatoloji
dc.subjectSağlık Bilimleri
dc.subjectRomatoloji
dc.titleNeuropsychiatric involvement in juvenile-onset systemic lupus erythematosus: A multicenter study
dc.typeMakale
dc.relation.journalJoint Bone Spine
dc.contributor.departmentErciyes Üniversitesi , ,
dc.identifier.volume90
dc.identifier.issue4
dc.contributor.firstauthorID4259544


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